莲蓝口服液的制备工艺研究

Study on Preparation Technology of Andrographis-isatidis Oral Liquid

为了确定莲蓝口服液的生产工艺参数,为莲蓝口服液的生产提供参考,以(R,S)-告依春含量、穿心莲内酯与脱水穿心莲内酯含量为依据,采用水提、水提醇沉的方法提取板蓝根和大青叶,醇提法提取穿心莲,筛选出各成分含量均较高的莲蓝口服液制备工艺。结果显示,穿心莲粗粉加10倍量85%乙醇进行渗漉提取,渗漉液中穿心莲内酯和脱水穿心莲内酯的含量最高;板蓝根和大青叶进行水煎浓缩,浓缩液中加入穿心莲渗漉液使乙醇最终体积分数为60%时进行醇沉,穿心莲、板蓝根、大青叶三者的质量比为1∶2∶1制备的莲蓝口服液各标示成分含量最高。

In order to optimize extraction process of andrographis-isatidis oral liquid and provide a reference for industrial production of this preparation,the research had been screened out the best abstraction technological conditions of andrographis-isatidis oral liquid by water extraction,water extraction and ethanol precipitation,with the content of R-S epigoitrin,andrographolide and dehydroandrographolide as the indexes. The results showed that the contents of andrographolide and dehydroandrographolide were the hightest,when the extraction condition was Andrographis paniculata with10 times amount of 85% ethanol. Concentration liquid was obtained by the methods of decoction and concentration of Isatis tinctoria and Isatis indigotica,percolation liquid were added to the concentration liquid for alcohol precipitation with the alcohol concentration of 60%. The active ingredient of andrographis-isatidis oral liquid peaked when the mass ratio of Andrographis paniculata,Isatis tinctoria and Isatis indigotica was 1∶ 2∶ 1.