复发性口腔溃疡中医证型与免疫状态研究

Study on TCM Syndrome Type and mmune State of Recurrent Aphthous Ulcer

目的:观察复发性口腔溃疡(recurrent aphthous ulcer,RAU)患者不同中医证型与免疫功能状态的关系。方法:随机选取80例为实验组和20例为健康对照组,通过辨证确立中医证型,分别用流式细胞仪检测T淋巴细胞亚群,免疫比浊法检测免疫球蛋白和补体C3、C4。结果:心脾积热型CD8+淋巴细胞升高,CD4+淋巴细胞和CD4+/CD8+比值降低,Ig G升高,补体C3、C4均降低;阴虚火旺型CD4+降低,Ig G升高,补体C4和Ig A降低;气血亏虚型Ig G升高,与健康对照组相比均有明显差异,其余指标与健康对照组比较无明显差异。结论:RAU患者存在免疫功能状态的失调,其可能是中医证型动态性发展的病理基础之一。

Objective ： To observe the relationship between different TCM syndrome type and immune state of recurrent aphthous ulcer （ RAU ） patients. Method： The patients were divided into 2 groups randomly, 80 cases in the experimental group and 20 cases in the healthy control group. TCM syndrome types were decided by differentiation of symptoms and signs. T lymphocyte subsets was detected by flow cytometry and immunoglobulin and the complement C3 and C4 were detected by immunoturbidimetry. Result： In brimming heat of the heart and spleen type, CDS＋ lymphocyte increased, CD4＋ lymphocyte and CDg＋/CD8＋ radio decreased, IgG increased and the complement C3 and C4 decreased. In Yin deficiency and fire excess type, CD4＋ lymphocyte decreased, IgG increased and the complement C4 and IgA decreased. In deficiency of both qi and blood type, IgG increased. There was significant difference compared with that of the healthy control group. There was no significant difference in the other index compared with that of the healthy control group.Conclusion： There is disorder of immune state in RAU patients, which could be one of the pathological basis of TCM syndrome type.