中国药典2015年版妊娠哺乳期禁忌相关中成药整理及思考

Thoughts upon Recording and Sorting-out the Chinese Patent Medicine Contraindications(Gestation & Lactation) in Chinese Pharmacopoeia(2015 Edition)

目的整理分析中国药典2015年版收载的中成药妊娠哺乳期用药,为临床药物咨询工作提供参考依据。方法统计中国药典2015年版一部所有中成药关于妊娠哺乳期禁忌的描述及其他用药注意事项,并进行分类。结果妊娠哺乳期用药禁忌所涉及的药物共计487种,包括妊娠期慎用药物192种,忌用药物有112种,禁用药物183种。其中,涉及哺乳期禁忌的用药共14种。此外,还有一些药物涉及妊娠常见并发症及合并症。结论中成药需依据中医药理论合理使用,任何单一、片面的论断都会增加用药风险。

OBJECTIVE To sort out the Chinese patent medicinal details of gestation and lactation period, which were included in Chinese Pharmacopoeia（2015 Edition）. This study provide information for clinical rational drug use. METHODS Statistically analyzed the all Chinese patent medicines of Pharmacopoeia in line with contraindications and announcements（gestation lactation）. RESULTS All of 487 species of Chinese patent medicine refer to announcements. In gestation related drugs, 192 species are administrated with caution for pregnant women, 112 species are defined to contraindicationin pregnancy, and 183 species are vividly divided into ＂Forbidden in pregnancy＂ domain. Another more, 14 types are related to lactation contraindication. In addition, some drugs are disadvantaged to pregnancy complications. CONCLUSION The use of Chinese patent medicine need to follow traditional theories. Any single, one-sided argument would increase the risk of medication.