摘要
目的按中国药典2015年版抑菌效力检查法测定苯酚滴耳液的抑菌效力。方法以金黄色葡萄球菌、铜绿假单胞菌、大肠埃希菌、黑曲霉和白色念珠菌为试验菌株,分别加入苯酚滴耳液中进行微生物的挑战试验,在不同时间点检测样品中微生物的存活情况。结果苯酚滴耳液的抑菌效力符合中国药典2015年版抑菌效力检查法的规定。结论苯酚滴耳液本身已具备充分的抑菌效力,可避免在贮藏和使用过程中发生微生物污染。
OBJECTIVE To study antimicrobial effectiveness of phenol ear drops by the Chinese Pharmacopoeia（2015 Edition）. METHODS Using Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Aspergillus and Candida albicans as test strains, the antimicrobial effectiveness test was carried out, to evaluate the survival of microorganisms at the different time. RESULTS The antimicrobial effectiveness of phenol ear drops met the requirements of the Chinese Pharmacopoeia（2015 Edition）. CONCLUSION Phenol ear drops possess an intrinsic antimicrobial activity, so as to protect them from growth of microorganisms inadvertently introduced during or subsequent to the manufacturing process.
出处
《中国现代应用药学》
CAS
CSCD
2016年第5期645-648,共4页
Chinese Journal of Modern Applied Pharmacy
关键词
苯酚滴耳液
抑菌效力
评价
phenol ear drops
antimicrobial preservatives
evaluation
