痰热清辅助治疗老年支气管扩张症合并感染的疗效分析

Clinical efficacy of Tanreqing in treating bronchiectasis combined with infection in the elderly

目的观察痰热清辅助治疗老年支气管扩张症合并感染的临床疗效。方法按入院顺序采用随机、对照的方法,将84例老年支气管扩张症合并感染患者分为观察组和对照组,每组各42例。对照组给予常规治疗,观察组在常规治疗基础上给予痰热清注射液治疗。2组疗程均为10~14 d。比较2组临床疗效、临床症状改善情况,观察2组治疗前、后血清降钙素原（PCT）、外周血白细胞（WBC）计数、红细胞沉降率（ESR）水平、肺功能、动脉血气分析等指标的变化及不良反应发生情况。结果观察组总有效率为95.24%,高于对照组的80.95%（χ2=4.086,P〈0.05）;观察组各临床症状改善时间均明显短于对照组（P〈0.01）;与治疗前比较,2组治疗后血清PCT均降低（P〈0.01）,观察组降低更明显（P〈0.05）;2组治疗前后及2组之间WBC、ESR比较,差异均无统计学意义（P〉0.05）;与治疗前比较,2组治疗后肺功能、动脉血氧分压（Pa O2）均改善（P〈0.05,P〈0.01）,观察组改善更明显（P〈0.05）;2组治疗前后及2组之间p H、动脉血二氧化碳分压（Pa CO2）比较,差异均无统计学意义（P〉0.05）;2组均未发生严重不良反应。结论对于老年支气管扩张症合并感染患者,在常规治疗基础上加用痰热清能协同控制感染,改善症状,显著提高疗效。

Objective To investigate the clinical effect of Tanreqing as adjuvant treatment for bronchiectasis combined with infection in elderly patients. Methods Eighty-four cases of elderly patients with bronchiectasis complicated with infection were randomly divided into observation group and control group according to admission sequence,with 42 cases in each group. All patients were given the conventional therapy,and the observation group was treated with Tanreqing additionally. The treatment lasted for 10-14 d. The therapeutic effect of the two groups after treatment was evaluated,and the clinical features,serum procalcitonin（ PCT） level,peripheral white blood cell（ WBC） count,erythrocyte sedimentation rate（ ESR）,lung function,arterial blood gas analysis,and adverse reaction were observed before and after treatment. Results The total effective rate was 95. 24% in the observation group,compared with 80. 95% in the control group（ χ2= 4. 086,P〈0. 05）. After treatment,the improvement time of the clinical features in observation group was shorter than that in the control group（ P〈0. 01）. Compared with before treatment,serum PCT level of the two groups after treatment decreased（ P〈0. 01）,especially in observation group（ P〈0. 05）. Compared with before treatment,WBC,ESR of the two groups after treatment showed no significant difference（ P〈0. 05）. Compared with before treatment,lung function and Pa O2 were improved in the two groups after treatment（ P〈0. 05,P〈0. 01）,and especially in observation group（ P〉0. 05）. Compared with before treatment,p H,Pa CO2 of the two groups after treatment showed no significant difference（ P〉0. 05）. No serious adverse reaction was found in the two groups. Conclusions For elderly patients with bronchiectasis complicated with infection,the conventional therapy combined with Tanreqing can synergistically control infection,relieve clinical symptoms and improve the clinical effect significantly.