血清脂蛋白(a)与冠心病的相关性分析

Correlation of lipoprotein (a) with coronary heart disease

目的分析血清脂蛋白(a)[Lp(a)]水平与冠心病(CHD),以及其他心血管疾病危险因素的相关性。方法对入选的72例CHD支架置入患者、199例未置入支架的CHD患者、226例非CHD患者血清中的Lp(a)水平进行测定,比较不同组间Lp(a)水平的差异,分析Lp(a)与CHD及血脂的相关性。结果 CHD支架置入患者的Lp(a)水平为(347.47±273.97)mg/L,CHD患者为(305.48±254.73)mg/L,非CHD患者为(269.72±206.21)mg/L,CHD支架置入患者Lp(a)水平明显高于非CHD患者(P<0.05),其他组间差异无统计学意义(P>0.05)。结论 Lp(a)与CHD有关,尤其在支架置入患者中最高,提示我们应对其在CHD发生发展中的作用进行更深入的研究。

Objective To analyze the relationship of serum level of lipoprotein（ a） [Lp（ a） ] with coronary heart disease（ CHD） and serum lipid. Methods Seventy-two CHD patients with intracoronary stent implantation,199 CHD patients without intracoronary stent implantation and 226 cases without CHD were enrolled in this study. The serum levels of Lp（ a） were measured and compared among three groups. Results Levels of Lp（ a） was 347. 47 ± 273. 97 mg / L in CHD patients with intracoronary stent implantation,and 305. 48 ± 254. 73 mg / L in CHD patients without intracoronary sent implantation,and 269. 72 ± 206. 21 mg / L in control group. The level of Lp（ a） in patients with intracoronary stent implantation was significant higher than that in the control group（ P = 0. 01）. There were no significant difference in levels of Lp（ a） between other groups（ P〉0. 05）. Conclusions Lp（ a） is associated with CHD,and the level of Lp（ a） is highest in the patients with intracoronary steat implatation,which suggests that we should pay more attention to the role of Lp（ a） in the development of CHD.