肺癌患者血清CEA,CA19-9,CA125及CA153围手术期动态监测的临床意义

Clinical Significance of Monitoring Preoperative CEA,CA19-9,CA125 and CA153 in Patients with Lung Cancer

目的:探讨动态监测肺癌患者围手术期血清CEA、CA19-9、CA125及CA153水平变化的临床意义。方法:随机选取2014年5月至2015年5月收治的肺癌患者58例为研究对象,另选取同期在我院接受体检的健康人群15例为对照组。分别测定肺癌患者手术前及术后1天、1周、1个月、3个月的血清CEA、CA19-9、CA125、CA153水平,并与对照组的上述各血清肿瘤标志物进行比较。结果:肺癌患者术前空腹血清CEA、CA19-9、CA125、CA153水平明显高于对照组,差异具有统计学意义(P<0.01)。肺癌患者术后1天、1周、1个月及3个月的血清CEA、CA19-9、CA125、CA153水平明显低于术前,差异具有统计学意义(P<0.05)。肺癌患者术后1个月的平均空腹血清CEA、CA19-9、CA125、CA153水平高于术后3个月平均水平,但差异不具有统计学意义(P>0.05)。结论:对肺癌患者的血清CEA、CA19-9、CA125、CA153水平进行围手术期动态监测有助于评估手术治疗效果。

Objective： To explore the value of monitoring the dynamic changes of perioperative serum levels of CEA, CA19-9,CA125 and CA153 in patients with lung cancer. Methods： 58 patients with lung cancer who were treated in our hospital from May 2014 to May 2015 were selected as the cancer group, and another 15 healthy people who had taken the check-up in our hospital were chosen to be the control group. The serum levels of CA19-9, CA125, CA153 and CEA were measured before and 1 days, days, 1 weeks, 1months, 3 months after operation, and compared with those of the control group. Results： The levels of CEA, CA19-9, CA125 and CA153 in patients with lung cancer were significantly higher than those of the control group（P〈0.01）. The levels of serum CEA, CA125,CA19-9 and CA153 were significantly lower than the 1 day, 7 days, 1 week, 1 month and 3 months after surgery, and the difference was statistically significant（P〈0.05）. The average serum of CEA, CA19-9, CA153 and CA125 levels in patients with lung cancer were higher in 3 months after operation than before surgery, but the difference was not statistically significant（P〉0.05）. Conclusions： Dynamic monitoring of perioperative CEA, CA19-9, CA125 and CA153 in patients with lung cancer can indicate the clinical effects.