VEGF-A在食管鳞状细胞癌中的表达及临床意义

Expression and Clinical Significance of VEGF-A in Esophageal Squamous Cell Carcinoma

目的:探讨血管内皮生长因子A(VEGF-A)在食管鳞状细胞癌中的表达及临床意义。方法:收集2009年1月-2010年12月收治的45例食管鳞状细胞癌患者临床资料及病理标本,应用免疫组织化学法检测肿瘤组织VEGF-A表达及微淋巴管密度(MLVD),分析VEGF-A表达与食管鳞癌患者临床病理资料、MLVD及与患者生存期限的关系。结果:1有淋巴结转移的患者VEGF-A表达阳性率为66.67%,明显高于无淋巴结转移患者的38.10%(P<0.05);2 VEGF-A阳性食管鳞状细胞癌患者MLVD为(8.35±2.45)明显高于阴性患者的(5.32±1.44),(P<0.05);3VEGF-A阳性食管鳞状细胞癌患者3年存活率为41.67%明显低于阴性患者的61.90%(P<0.05)。结论:VEGF-A表达在确定早期食管鳞状细胞癌淋巴结转移方面具有一定的应用价值,可以作为评价预后的有效指标。

Objective： To investigate the expression and clinical significance of vascular endothelial growth factor A（VEGF-A） in patients with esophageal squamous cell carcinoma（ESCC）. Methods： The clinical pathological data of 45 patients with ESCC, who were admitted to Guang＇an People＇s Hospital from January 2009 to December 2010, were collected. The VEGF-A expression and micro lymphatic vessel density（MLVD） in tumor tissue were detected by immunohistochemical method. The relationship between VEGF-A expression and clinical pathological data, MLVD and survival period were analyzed. Results： The VEGF-A positive expression rate（66.67%） of patients with lymph node metastasis was significantly higher than that（38.10%） of patients without lymph node metastasis（P〈0.05）. The MLVD（8.35 ±2.45） in patients with VEGF-A positive expression was significantly higher than that（5.32 ±1.44） of patients with VEGF-A negative expression（P〈0.05）. The 3-year survival rate（41.67%） of patients with VEGF-A positive expression was significantly lower than that（61.90%） of patients with VEGF-A negative expression（P〈0.05）. Conclusion： VEGF-A expression has an application value in determining lymph node metastasis in patients with early esophageal squamous cell carcinoma,which could be used as an effective indicator of prognosis.