2016年脓毒症最新定义与诊断标准：回归本质重新出发

New definition and clinical criteria for sepsis and septic shock in 2016： back to the nature, head for the future

脓毒症是导致危重病患者死亡的主要原因之一.脓毒症和脓毒性休克的定义于1991年提出,于2001年修订.随着研究者对脓毒症病理生理机制研究的深入,以及脓毒症临床治疗的不断改观,美国重症医学会与欧洲重症医学会于2016年2月对脓毒症和脓毒性休克的定义予以更新.本文将回顾脓毒症定义的历史沿革,介绍脓毒症和脓毒性休克的最新定义,并展望该定义将产生的重要影响.脓毒症和脓毒性休克的最新定义和诊断标准,将为相关临床研究提供重要参考依据,有望在早期识别和治疗脓毒症患者中发挥关键作用.

Sepsis is a leading cause of death in critically ill patients.The definitions of sepsis and septic shock were introduced in 1991 and last revised in 2001.Since considerable advances had occurred to its pathophysiology and management,an update definitions for sepsis and septic shock were released in February 2016 by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine.This article is to review the development and limitations of previous versions of sepsis definition,and summarize the sepsis 3.0 definition and its clinical diagnosis criteria.These updated definitions and clinical criteria will play vital roles in providing important reference frame for clinical trials,and facilitating early recognition and timely management of patients with sepsis.