沙格雷酯治疗2型糖尿病伴下肢动脉硬化闭塞症患者的疗效评估

Type 2 Diabetic Patients with Lower Limb Arteriosclerosis Obliterans:Evaluation of Effect of Sarpogrelate

目的：探讨沙格雷酯治疗2型糖尿病伴下肢动脉硬化闭塞症（ASO）患者的临床疗效。方法：选择2014年4月～2015年5月我院2型糖尿病伴下肢ASO患者80例,给予口服沙格雷酯100 mg,3次/日,连续8周,监测治疗前后患肢的症状与体征、双下肢动脉峰值血流速度、血糖、血脂及血液流变学等指标的变化。结果：口服沙格雷酯8周后,患者疼痛感、冷感、间歇性踱行、麻木感及下肢溃疡等主观症状有效率均大于91%,临床总有效率为93.75%。治疗后患者左、右下肢动脉血管直径与治疗前比较,差异无统计学意义（P〉0.05）,但左、右下肢动脉峰值血流速度比治疗前显著降低,差异有统计学意义（P〈0.05）。治疗后患者的甘油三酯、总胆固醇、低密度脂蛋白、全血高切黏度及全血低切黏度比治疗前降低,差异有统计学意义（P〈0.05）。结论：沙格雷酯可改善2型糖尿病伴下肢ASO患者的症状,降低双下肢动脉峰值血流速度,临床疗效确切,值得临床推广应用。

Objective： To study the effect of sarpogrelate in the treatment of type 2 diabetic patients complicated with lower limb arteriosclerosis obliterans （ASO）. Methods： A total of 80 patients with type 2 diabetic complicated with lower limb ASO, who were treated in Zhangjiakou Second Hospital of Hebei Province from April 2014 to May 2015, were selected and given oral sarpogrelate（100 mg, 3 times/day） for eight weeks. The changes of symptoms and signs of the limbs, the double lower limbs artery peak flow velocity, blood glucose, blood lipid and blood rheology indexes before and after treatment were detected. Results： After 8 weeks of oral sarpogrelate, the effective rates of subjective symptom of pain, cold feeling, intermittent strolled, numbness and lower limb ulcer were more than 91%, and the clinical total effective rate was 93.75%. There were no significance in the left and right lower limb artery diameter compared with before treatment （P〉0.05）, but the left and right lower limb artery peak flow was reduced compared with before treatment, the difference was statistically significant （P〈0.05）. The levels oftriglyceride, total cholesterol, low density lipoprotein, whole blood high shear viscosity and whole blood low shear viscosity were lower than before treatment, the difference was statistically significant （P〈0.05）. Conclusion： Sarpogrelate can improve the symptoms of type 2 diabetes patients with lower limb arteriosclerosis obliterans and reduce the lower limb artery blood flow velocity, with a definite clinical effect, which is worthy of clinical application.