氢吗啡酮术后镇痛对直肠癌Dixon术后肠功能的影响

Effect of Postoperative Analgesic Hydromorphone on the Recovery of Bowel Function after Dixon Operation

目的:探讨氢吗啡酮术后镇痛对直肠癌患者Dixon术后肠功能恢复的影响。方法:选择直肠癌行Dixon术的患者36例,随机分为氢吗啡酮组(H组)和吗啡组(M组),每组18人。两组患者均行静脉自控术后镇痛,其中H组镇痛药物采用氢吗啡酮+昂丹司琼,而MS组则采用吗啡+昂丹司琼。术后常规医疗处理。结果:两组患者在年龄、性别、文化程度无统计学差异(P>0.05)。两组患者术后VAS评分及HR、MAP变化均没有统计学差异(P>0.05)。与M组相比,H组患者术后不良反应的发生率明显降低(P<0.05),肠鸣音恢复时间、术后第一次排气时间和第一次排便时间均明显缩短(P<0.05)。结论:相对于吗啡,氢吗啡酮用于术后镇痛更有利于直肠癌患者术后肠功能的恢复,并减少术后不良反应的发生率。

Objective： To investigate the effect of postoperative analgesic hydromorphone on the recovery of bowel function in patients after Dixon operation. Methods： 36 rectal cancer patients that requiring Dixon operation were selected in this study. Patients were randomly divided into Hydromorphone group （Group H） and Morphine group （Group M）, 18 patients each group. Patients in Group H were treated with hydromorphone and ondansetron for postoperative analgesia. While in Group M, patients were received morphine and ondansetron as postoperative analgesic. Results： There were no difference in gender, age, educational level between two groups （P〉0.05）. The HR, MAP and score of VAS were not different （P〉0.05） between two groups. Compared with Group M, the complications incidence rate after operation was significantly reduced in Group H （P 〈 0.05）. Shorten recovery time of bowel sounds, anal aerofluxus and defecation was recorded in Group H （P 〈 0.05）. Conclusion： The hydromorphone can help reducing the incidence of negative reactions and benefit bowel function recovery in patients with rectal cancer after Dixon operation.