12例胃炎性纤维性息肉临床病理分析

A clinicopathologic analysis of 12 cases with gastric inflammatory fibroid polyps

目的探讨胃炎性纤维性息肉（IFP）的临床病理特点、诊断和鉴别诊断。方法回顾性分析12例IFP的临床资料、病理特征、随访情况。结果男2例,女10例,年龄40-66岁,平均年龄53.9岁。12例部位均位于胃窦。病变大小0.7-3.0cm。主要临床表现为中上腹部疼痛。胃镜下呈息肉样突起。镜下肿块由较温和的短梭形细胞组成,呈交织的束状或席纹状排列。梭形细胞可围绕血管呈具有特征性的＂洋葱皮＂样改变。背景有较多炎细胞,尤其是嗜酸性粒细胞。免疫组织化学染色梭形细胞表达CD34（12/12）。随访12例患者均无复发。结论 IFP是一种少见消化道良性肿瘤,诊断需结合临床病理特点,主要与胃肠道间质瘤鉴别。

Objective To investigate the clinicopathologic features,diagnosis and differential diagnosis of inflammatory fibroid polyps（IFP）.Methods A total of 12 cases of IFP were retrospectively reviewed on the clinical data,the follow-up data,histological and immunohistochemical features.The related literatures were reviewed.Results Among 12 cases,2were males and 10 were females,with age ranging from 40 to 66years（average age was 53.9years）.The lesions all occurred in gastric antrum and ranged in size from 0.7to 3.0cm.Most patients had abdominal pain.Histopathologically,IFP was composed of bland spindle cells arranged in fascicular growth or storiform pattern.A prominent concentric perivascular fibroblastic proliferation（onion skinning）and eosinophilic infiltrate were often observed.Immunohistochemical findings showed the tumor cells were positive for CD34（12/12）and no recurrence found by follow-up visit.Conclusion IFP is a rare benign tumor in digestive tract.The diagnosis depends on the clinical and histological features and should differentiate from gastrointestinal stromal tumor.