咳嗽变异性哮喘患儿接受疏风化痰通络汤治疗后气道功能以及血清指标、诱导痰指标评估

Assessment of airway function as well as serum and induced sputum indicators after children with cough variant asthma received Shufeng Huatan Tongluo Decoction

目的研究咳嗽变异性哮喘患儿接受疏风化痰通络汤治疗后的气道功能以及血清指标、诱导痰指标。方法选择2012年5月至2105年10月期间收治的78例咳嗽变异性哮喘患儿作为研究对象,随机分为西药治疗组和联合治疗组,比较两组患儿气道功能指标、血清指标、诱导痰指标的差异。结果治疗后8周时,观察组患儿治疗后的用力呼气50%流速(FEF50)、用力呼气75%流速(FEF75)、最大呼气中期流速(MMEF75/25)水平显著高于西药治疗组,血清Ig E、肿瘤坏死因子α(TNF-α)、白细胞介素8(IL-8)含量以及诱导痰嗜酸性粒细胞(EOS)、碱基蛋白(MBP)、EOS阳离子蛋白(ECP)、EOS衍生性神经毒素(ENP)、EOS过氧化酶(EPC)含量显著低于西药治疗组,人Clara细胞分泌蛋白(CCSP)含量显著高于西药治疗组,两组间的差异有统计学意义(P<0.05)。结论疏风化痰通络汤能够改善咳嗽变异性哮喘患儿的气道功能,同时能够减轻Ig E以及EOS所介导的变态反应、炎症反应以及气道损伤。

Objective To study the airway function as well as serum and induced sputum indicators after children with cough variant asthma receiving Shufeng Huatan Tongluo Decoction. Methods 78 cases of children with cough variant asthma who were treated in our hospital from May 2012 to October 2015 were selected as research subjects and randomly divided into western medicine therapy group and combined treatment group. And then differences in airway function indicators,serum indicators and induced sputum indicators were compared between two groups. Re-sults FEF50,FEF75 and MMEF75 /25 levels of observation group 8 weeks after treatment were significantly higher than those of western medicine therapy group after treatment. IgE,TNF- α and IL- 8 levels in serum as well as EOS,MBP,ECP,ENP and EPC levels in induced sputum were significantly lower than those of western medicine therapy group. CCSP level was significantly higher than that of western medicine therapy group,and differences between two groups were statistically significant（ P〈0. 05）. Conclusion Shufeng Huatan Tongluo Decoction can improve the airway function of children with cough variant asthma,and can also reduce the allergy,inflammation and airway injury mediated by Ig E and EOS.