锚蛋白1在老年冠心病患者外周血中的表达水平及其辅助诊断价值

The expression of serum ankyrin 1 in patients with coronary heart disease and its auxiliary diagnosis value

目的探讨锚蛋白1(ANK1)对老年冠心病的辅助诊断价值,以期为临床诊疗提供参考。方法纳入2013年1月至2015年1月收治的冠心病患者56例,并列为观察组。另外纳入同期健康体检的50例老年人作为对照组。检测两组ANK1及相关炎症因子水平,并采用ROC曲线分析其对冠心病的诊断价值。结果观察组患者外周血ANK1、C反应蛋白(CRP)及白细胞介素6(IL-6)水平均显著高于对照组(P<0.05)。观察组患者外周血ANK1水平与IL-6及CRP均呈现显著正相关(P<0.05)。ROC曲线分析显示,以96.04 ng/ml为截点值,ANK1诊断冠心病的敏感度为89.29%,特异度为84.00%,曲线下面积为0.86,优于IL-6及CRP。结论冠心病患者外周血ANK1水平显著升高,且与IL-6及CRP水平呈正相关,可一定程度上反映机体系统性炎症水平。ANK1对老年冠心病具有一定辅助诊断价值。

Objective To analyze the expression of serum ankyrin 1（ ANK1） in patients with coronary heart disease and to evaluate its auxiliary diagnosis value. Methods Clinical data of patients with coronary heart disease received treatment at our hospital from 2013 to 2015 were analyzed as Group A. Healthy cases were enrolled as Group B. Results A total of 106 cases were analyzed,Group A 56 cases,Group B50 cases. Group A patients had higher levels of ANK1,IL- 6 and CRP than those of Group B,the difference were statistically significant（ P〈0. 05）. Correlation analysis showed that,for Group A patients,the levels of ANK1 had significant positive correlation with IL- 6 and CRP（ P〈0. 05）. ROC analysis showed that the ANK1 cut- off point value of 96. 04 ng /ml,as used for the diagnosis of coronary heart disease,provided a sensitivity of 89. 29 %,a specificity of 84. 00 %,better than these of IL- 6 and CRP. Conclusion The levels of ANK1 increased significantly in patients with coronary heart disease,which showed an auxiliary diagnosis value.