老年慢性阻塞性肺疾病患者的血清激活素A和转化生长因子β1与肺功能变化的相关性

Clinic significance and correlations of serum activin A,transforming growth factor beta 1 and pulmonary function of elderly patients with chronic obstructive pulmonary disease

目的探讨老年慢性阻塞性肺疾病(COPD)患者的血清激活素A(ACTA)和转化生长因子β1(TGF-β1)与肺功能变化的相关性。方法选择于2014年9月至2015年9月收治的老年COPD患者95例作为研究对象,选取同期60例健康体检者作为对照组。采用酶联免疫吸附法(ELISA)法检测血清ACTA和TGF-β1水平。采用Pearson相关性分析法分析ACTA和TGF-β1水平与各肺功能指标的相关性。结果与健康对照组相比,老年COPD患者的ACTA和TGF-β1水平显著升高(P<0.05)。COPD严重程度越高,ACTA和TGF-β1水平越高(P<0.05)。肺功能损伤等级越高,ACTA和TGF-β1水平随之显著增高(P<0.05)。Pearson相关性分析结果显示,老年COPD患者血清ACTA和TGF-β1与FEV1%呈显著负相关(r=-0.687,-0.751,P<0.05),血清ACTA和TGF-β1与FEV1/FVC呈显著负相关(r=-0.613,-0.598,P<0.05)。结论 ACTA和TGF-β1在老年COPD患者的病情进展中具有重要作用,且与肺功能变化具有相关性。

Objective To explore the clinic significance and correlations of serum activin A,transforming growth factor β1 and pulmonary function of elderly patients with chronic obstructive pulmonary disease. Methods 95 patients with elderly COPD were collected as the research object from September 2014 to September 2015. Sixty healthy subjects served as controls. The concentrations of ACTA and TGF- β1 were determined using ELISA. The pearson correlation test was performed to analyze the correlation between ACTA,TGF- β1 and pulmonary function index. Results Compared with those in healthy controls,plasma ACTA and TGF- β1 levels in elderly COPD increased significantly（ P〈0. 05）.The higher of the COPD level,the higher the level of ACTA and TGF- beta 1（ P〈0. 05）. The higher the level of pulmonary function damage,the higher the level of ACTA and TGF- beta 1. Pearson correlation analysis showed that the serum levels of ACTA,TGF- β1 were negatively correlated with FEV1%（ r =- 0. 687,- 0. 751,P〈0. 05）,and they were also negatively correlated with FEV1 / FVC（ r =- 0. 613,- 0. 598,P〈0. 05）. Conclusion ACTA and TGF- β1 play important roles in the progression of COPD,and have correlation with pulmonary function changes.