穴位埋线对慢性荨麻疹患者血清IL-4、IFN-γ和IgE的影响

Effect of Point Embedding Therapy on Serum IL-4,IFN-γ and Ig E in Patients with Chronic Urticaria

目的探讨穴位埋线疗法对慢性荨麻疹患者血清IL-4、IFN-γ以及Ig E水平的影响。方法选取就诊的慢性荨麻疹患者120例,随机分为A组和B组各60例。同时选取30例健康人群作为对照组。A组采用盐酸西替利嗪片口服治疗,B组采用穴位埋线疗法进行治疗。比较A组和B组的疗效,同时比较A组和B组治疗前后以及对照组的血清IL-4、IFN-γ以及Ig E水平。结果 B组的痊愈率为31.67%,总有效率为71.67%;A组的痊愈率为13.33%,总有效率为53.33%。B组的痊愈率和总有效率均显著高于A组(2=5.783,4.302,P<0.05),A组和B组治疗前的IL-4、Ig E水平均显著高于对照组,而IFN-γ水平则显著低于对照组(均P<0.05);A组和B组治疗后的IL-4、Ig E水平均显著低于治疗前,而IFN-γ水平则显著高于治疗前(均P<0.05);B组治疗后的IL-4为(27.51±6.25)pg/m L,Ig E为(68.59±15.35)IU/m L,均显著低于A组治疗后,而IFN-γ为(25.18±3.63)ng/m L,显著高于A组治疗后。结论穴位埋线疗法可显著降低慢性荨麻疹患者的血清IL-4、Ig E水平,提高IFN-γ的水平,提高慢性荨麻疹的临床疗效。

Objective To investigate the effect of point embedding therapy on serum IL - 4, IFN -γ, and IgE in patients with chronic urticaria. Methods One hundred and twenty patients with chronic urticaria in our hospital were evenly randomized into Group A and Group B. 30 healthy subjects were also selected as the control group at the same time. Group A were treated with cetirizine hydrochloride oral treatment while Group B were treated with point embedding therapy. The clini- cal efficacy of Group A and Group B were compared, so did the serum IL - 4, IFN -γ, and IgE level of Group A, Group B, and the control group before and after the treatment. Results The cure rate was 31.67% in Group B while its total effective rate was 71.67% , and that statistics were 13.33% and 53.33% in Group A respectively. The cure rate and total effective rate in group B were significantly higher than those in group A （Z2 =5. 783,4. 302, P 〈0. 05）. IL -4 and IgE levels in Group B and Group A before the treatment was significantly higher than those of the control group, whereas the IFN -γ levels were significantly lower than those of the control group （ P 〈 O. 05 ） ; IL - 4 and IgE levels in Group A and Group B after the treatment were significantly lower than before treatment, and IFN -γ levels were significantly higher than those before treat- ment （P 〈0. 05）. The IL -4 and IgE levels of Group B after treatment were （27.51±6. 25） pg/mL and （68.59 ± 15.35） IU/ mL, which were significantly lower than those of Group A after treatment. However, the IFN -γ was （25.18 ± 3.63 ） ng/ mL, which was significantly higher than that of Group A. Conclusion Point embedding therapy can significantly decrease serum IL - 4 and IgE level, and improve IFN -γ level of patients with chronic urticaria, resulting in the improvement of cur- ative effect among patients.