老年及不同老龄段脊柱椎体骨密度测定研究

A study of bone mineral density in vertebral bodies of old people of different age groups

目的 研究老年及各老龄段T3至L5椎体骨密度值。方法 用外周骨定量CT(pQCT)仪测量 4 0具老年尸体 6 0 0个椎体的总骨密度 ,松质骨密度 ,皮质下骨密度 ,皮质骨密度 ,椎体横断面总面积 ,松质骨面积 ,皮质下骨面积 ,皮质骨面积及皮质骨厚度。分别统计 6 0～ 6 9岁 (A组 )、70～ 79岁(B组 )、80～ 89岁 (C组 )、90～ 98岁 (D组 )椎体骨密度值。结果 T3至L5椎体总骨密度为 188 2 5～191 6 0mg cm3,松质骨密度为 12 8 0 1～ 130 6 6mg cm3,皮质下骨密度为 4 5 4 90～ 4 6 1 87mg cm3,皮质骨密度为 76 4 13～ 76 9 5 5mg cm3。 6 0～ 79岁椎体总骨密度值保持在相对稳定水平 ,80岁以后该值下降较明显。结论 为国内开展脊柱骨质疏松症研究及椎体pQCT测量提供参考数据 。

Objective\ To study bone mineral density (BMD) in T\-3 to L\-5vertebral bodies of old people of different age groups. Methods\ Six hundred vertebral bodies from 40 elderly cadavers were measured by peripheral quantitative CT for total BMD,trabecular BMD,subcortical BMD,cortical BMD,total vertebral cross\|sectional area,trabecular bone cross\|sectional area,subcortical bone cross\|sectional area,cortical bone cross\|sectional area and cortical thickness.The bone mineral densities in 60～69 of age (group A),70-79 of age(group B),80-89 of age (group C) and 90-98 of age (group D) were analysed statistically. Results\ For T\-3 to L\-5 vertebral bodies,the total BMD was 188\^25-191\^6 mg/cm\+3,the trabecular BMD 128\^01-130\^66 mg/cm\+3,the subcortical BDM 454\^90-461\^87 mg/cm\+3,and the cortical BMD 764\^13-769\^55 mg/cm\+3.The total density in 60-79 of age maintained at relatively stable level.But,these values descended obviously after 80 years of age. Conclusion\ This study provides reference data for work in osteoporosis and the measurements of vertebrae by pQCT in China.It also lays the foundation for comparing bone densities in Chinese with those in Europeans.\;