南通地区非霍奇金淋巴瘤患者乙型肝炎病毒感染情况调查

The analysis of hepatitis B virus infection among Non-Hodgkin lymphoma patients in Nantong City

目的 :了解南通地区初治非霍奇金淋巴瘤(NHL)患者乙型肝炎病毒的感染情况。方法 :回顾性分析138例初治NHL患者临床资料,统计HBV血清学标志阳性患者的比例,并与同期急诊外伤患者HBV检出率比较。结果:138例NHL患者HBs Ag阳性率13.77%,明显高于对照组5.82%,差异有统计学意义(P=0.045);抗-HBc阳性率36.96%低于对照组54.37%,差异有统计学意义(P=0.011)。B细胞NHL与T细胞NHL患者HBs Ag阳性率、HBs Ab阳性率、Hbc Ab阳性率差异无统计学意义(4.17%vs 15.79%,54.17%vs 51.75%,41.67%vs 35.09%,P>0.05)。结论:在南通地区NHL患者HBV感染率高于普通人群,与NHL的发病有一定的关联。

Objective：To analyze the hepatitis B virus（HBV） infection status of the newly diagnosed Non-Hodgkin lymphoma（NHL） patients in Nantong City. Methods：The positive rate of serum HBV markers in 138 patients of NHL who were admitted. The emergency trauma patients were also enrolled as contro1. Results：The positive rate of HBs Ag was significantly higher in NHL patients than that in emergency trauma patients（13.77% vs 5.82%, P=0.045）.The positive rate of anti-HBc was significantly lower in NHL patients（36.96% vs 54.37%, P=0.011）.The positive rates of HBs Ag, anti-HBs and anti-HBc in B-cell NHL and T-cell NHL were not significantly different（4.17% vs 15.79%,54.17% vs 51.75%,41.67%vs 35.09%, P〉0.05）. Conclusion：The infection rate of HBV in NHL patients is higher than that in general population.HBV infection may play important roles in the development of NHL.