甲亢厌食和高钙血症的关系分析—临床随机对照研究

Relationship study between anorexia of hyperthyroidism and hypercalcemia—a clinical randomized controlled trial

目的 研究甲亢患者厌食和高钙血症及其他因素的关系。方法 随机选择 17例表现厌食的未治疗甲亢和 2 9例无厌食的未治疗甲亢患者 ,比较两组的血清游离钙、肝功能和焦虑评分。结果 治疗前两组血清游离钙分别是 (1 2 8± 0 0 8)mmol L和 (1 2 7± 0 0 8)mmol L ,显著高于正常对照组 ,但两组之间没有显著性差别 ;厌食组肝功能异常的人数和焦虑评分都明显高于无厌食组。结论 研究结果不能证明甲亢厌食和高钙血症之间有关系 ,肝功能异常和焦虑可能是甲亢厌食的危险因子。

Objective\ To study the relationship between anorexia and hypercalcemia in Graves'disease. Methods\ We studied 17 consecutive patients of untreated hyperthyroidism with anorexia,and 29 patients of untreated hyperthyroidism without anorexia,and compared the patients'age,serum free calcium,liver function and emotional condition,specifically the level of anxiety (using SAS Chinese version)before or/and after antithyroid drug therapy in the two groups. Results\ The free serum calcium were(1 28±0 08) mmol/L and (1 27±0 08) mmol/L in the group with anorexia(A)and the group(B) without anorexia before the treatmet,was significantly higher than health group,but there was no different between A and B group.The patient number with abnormal liver function or anxiety in A group was more than in B group. Conclusion\ Our study suggested that the causes of anorexia in untreated hyperthyroidism are complicated.Abnormal liver function,and the level of anxiety are significantly related to anorexia in untreated hyperthyroidism,but hypercalcemia was not confirmed to be related to anorexia in our study.\;