解毒通络生津方治疗原发性干燥综合征的临床观察

Clinical Observation of “Jiedu Tongluo Shengjin Formula” in Treating Patients with Primary Sjogren's Syndrome

目的:探讨解毒通络生津方治疗轻度原发性干燥综合征(primary Sjogren’s Syndrome,p SS)患者的临床疗效。方法:纳入90例轻度p SS患者,随机分成治疗组和对照组,每组45例。治疗组采用解毒通络生津方治疗,对照组采用硫酸羟基氯喹片治疗,疗程为12周。分别于治疗前后检测两组患者的外周血C反应蛋白(C-reactive protein,CRP)、血沉(erythrocyte sedimentation rate,ESR)及人软骨糖蛋白-39(YKL-40)的水平,并比较两组患者的p SS疾病活动度指数(Sjogren’s Syndrome disease activity index,SSDAI)评分的变化。结果:治疗后,两组患者的CRP、ESR及血清YKL-40水平较治疗前均明显降低(P<0.01),且治疗组患者的CRP、ESR及血清YKL-40水平低于对照组(P<0.01)。治疗后,两组患者的SSDAI评分较治疗前均明显降低(P<0.01),且治疗组患者的SSDAI评分低于对照组(P<0.01)。结论:解毒通络生津方可明显降低轻度p SS患者的疾病活动度,缓解病情发展,其作用机制可能与调节体内失调的免疫反应进而发挥有效的抗炎作用有关。

Objective： To investigate the therapeutic effect of＂Jiedu Tongluo Shengjin Formula＂in treating patients with mild primary Sjogren＇s Syndrome（ p SS）. Methods： A total of 90 patients with mild p SS were selected and randomly divided into the treatment group and the control group with 45 cases in each group. The patients in the treatment group were treated with＂Jiedu Tongluo Shengjin Formula＂and the patients in the control group were treated with hydroxychloroquine,with a course of 12 weeks. The levels of C-reactive protein（ CRP） in serum,erythrocyte sedimentation rate（ ESR） and YKL-40 of patients in both groups were detected before and after treatment,and the scores of Sjogren＇s Syndrome disease activity index（ SSDAI） were evaluated. Results： After treatment,the levels of serum CRP,ESR and YKL-40 in both groups were significantly decreased（ P〈0. 01）,and the levels of serum CRP,ESR and YKL-40 in the treatment group were lower than those in the control group（ P〈0. 01）. After treatment,the SSDAI scores of both groups were obviously decreased（ P〈0. 01）,and the scores of the treatment group were lower than those of the control group（ P〈0. 01）. Conclusion： ＂Jiedu Tongluo Shengjin Formula＂ could obviously reduce the disease activity of mild p SS and alleviate the disease progression,and its mechanisms may be related with the function of regulating the immune disorder and anti-inflammatory effect.