期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

miR-199a在肿瘤中的研究进展 被引量：5

Research Progress of MiR-199a on Cancer
原文传递
导出
摘要 MicroRNAs（miRNAs）是一类内源的、长度约为20-25个核苷酸非编码单链小RNA分子,在多种生理病理过程特别是肿瘤疾病中发挥着重要的作用。越来越多的证据表明,miR-199a在人类恶性肿瘤中异常表达。文章综述了miR-199a在肿瘤中作业及miR-199a-5p/3p成熟体调控机制。 MicroRNAs（ miRNAs） are a class of short（ 20 - 25 nucleotides in length） endogenous,single-stranded,non-coding RNAs,mainly involving in the post-transcriptional regulation,and they play an important role in many physiological and pathological process,especially in the tumor diseases. More and more evidences showed that miR-199 a expressed abnormally in human malignant tumors. In this paper,we mainly discuss research progress related miR-199 a tumor development,the role of diagnosis and treatment in precision medicine.
作者 马中良 李雪 梁辰 金由辛
机构地区 上海大学生命科学学院
出处 《药物生物技术》 CAS 2016年第2期155-158,共4页 Pharmaceutical Biotechnology
基金 国家自然基金项目(No.31170750) 抗肺癌药物的开发(校企合作)
关键词 MIRNA miR-199a 肿瘤 调控 MicroRNA miR-199a Tumor Regulation
分类号 Q524 [生物学—生物化学]
  • 相关文献

参考文献31

  • 1Malicki J. The importance of accurate treatment planning, delivery, and dose verification [ J ]. Rep Pract Oncol Radiother, 2012,17 (2) :63-65.
  • 2张冰洁,金由辛,马中良.microRNA在肿瘤中的作用[J].自然杂志,2014,36(5):364-372. 被引量：4
  • 3Lagos-Quintana M, Rauhut R, Meyer J, et al. New microRNAs from mouse and human[J].RNA,2003,9(2) :175-179.
  • 4Gu S, Chan WY.' Flexible and versatile as a chameleon-sophisti- cated functions of microRNA-199a [ J]. Int J Mol Sci, 2012,13 (7) :8449-8466.
  • 5Gailhouste L, Ochiya T. Cancer-related microRNAs and their role as tumor suppressors and oncogenes in hepatocellular carcinoma [ J ]. Histol Histopathol, 2013,28 (4) :437- 451.
  • 6Lee JM,Heo MJ, Lee CG,et al. Increase of miR-199a-5p by pro- toporphyrin IX, a photocatalyzer, directly inhibits E2F3, sensiti- zing mesenchymal tumor cells to anti-cancer agents[ J]. Oncotar- get,2015,6(6) :3918-3931.
  • 7Zhang L, Lyer AK, Yang X, et al. Polymeric nanoparticle-based delivery of microRNA-199a-3p inhibits proliferation and growth of osteosarcoma ceils [ J ]. lnt J Nanomed,2015 ,10 :2913-2924.
  • 8Jin N,Jin X,Gu X,et al. Screening biomarkers of bladder cancer using combined miRNA and mRNA microarray analysis [ J ]. Mol Med Rep ,2015 ,12( 2 ) :3170-3176.
  • 9Marquardt JU, Andersen JB, Thorgeirsson SS. Functional and genetic deconstruction of the cellular origin in liver cancer [ J ]. Nat Rev Cancer,2015,15( 11 ) :653-667.
  • 10Guo W, Qiu z, Wang Z,et al. MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer [ J ]. Hepatology, 2015, 62(4) :1132-1144.

二级参考文献35

  • 1Bartel D P. MicroRNAs:Target recognition and regulatory func-tions [ J]. Cell ,2009,136 ( 2 ) :215-233.
  • 2Salmena L, Poliseno L, Tay Y, et al. A ceRNA hypothesis:The rosetta stone of a hidden RNA language [ J ]. Cell,2011,146 (3) : 353-358.
  • 3Park S M, Peter M E. microRNAs and death receptors[ J ]. Cyto- kine Growth Factor Rev,2008,19(3-4) :303-311.
  • 4Filipowicz W, Bhattacharyya S N, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs : are the answers in sight[J]. Nat Rev Genet,2008,9(2) :102-114.
  • 5Chua J H, Armugam A, Jeyaseelan K. MicroRNAs: biogenesis, function and applications [ J ]. Curr Opin Mol Ther ,2009 ,11 ( 2 ) : 189-199.
  • 6Arvey A, Larsson E, Sander C, et al. Target mRNA abundance dilutes microRNA and siRNA activity [ J ]. Mol Syst Biol, 2010, 6:363.
  • 7Tay Y, Kats L, Salmena L, et al. Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs [J]. Cell,2011,147(2) :344-357.
  • 8Yang J,Li T,Gao C,et al. FOXO1 3'UTR functions as a eeRNA in repressing the metastases of breast cancer cells via regulating miRNA activity[ J]. Febs Letters,2014,588(17) :3218-3224.
  • 9Fang L, Du W W, Yang X, et al. Versiean 3 '-untranslated region (3'-UTR) functions as a eeRNA in inducing the development of hepatocellular carcinoma by regulating miRNA activity [ J ]. FASEB J,2013,27(3 ) :907-919.
  • 10Cesana M, Caechiarelli D, Legnini I, et al. A long noneoding RNA controls muscle differentiation by functioning as a competing endogenous RNA[J]. Cell,2011,147(2) :358-369.

共引文献4

同被引文献25

引证文献5

二级引证文献15

药物生物技术
2016年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部