阿托伐他汀对冠状动脉慢血流患者血管内皮功能的影响

Effects of atorvastatin on vascular endothelial function of patients with cronary slow flow

目的:了解阿托伐他汀对冠状动脉慢血流(coronary slow flow,CSF)患者内皮功能的影响。方法:选择行冠状动脉造影(coronary angiography,CAG)证实是冠状动脉慢血流的患者113例,随机分为对照组(30例)、剂量1组(28例)、剂量2组(28例)和剂量3组(27例)。对照组给予常规治疗,即用阿司匹林和单硝酸异山梨酯治疗,各剂量组在常规治疗基础上分别加阿托伐他汀10,20和40 mg/d,治疗3个月。检测血清内皮素-1(ET-1)、白介素-6(IL-6)和一氧化氮(NO)等内皮功能指标。结果:治疗后各观察组ET-1及IL-6浓度较对照组降低,差异有统计学意义(P<0.05)。各剂量组NO水平较对照组升高,差异有统计学意义(P<0.05)。结论:阿托伐他汀治疗能明显改善冠状动脉慢血流患者内皮功能。

Objective：To investigate the effects of atorvastatin on endothelial function of patients with coronary slow flow（CSF）.Methods：113 patients with CSF were included by coronary angiography and randomly divided into control group（30 cases） and dosage group 1（28 cases）,dosage group 2（28 cases）,dosage group 3（27 cases）.Control group were given conventional treatment of aspirin and isosorbide mononitrate sustained release tablets;dosage group were treated with additional atorvastatin 10 mg/d,20 mg/d,40 mg/d.The treatment duration was3 months.The serum endothelin-1（ET-1）,IL-6,nitric oxide（NO） levels were measured before and after treatment.Serum ET-1 and IL-6 level were measured by ELISA and serum NO was detected by chromatometry.Results：After 3 months treatment the serum ET-1 and IL-6 levels decreased in each observation group,lower than those in the control group with statistical significance（P〈0.05）.The serum NO levels in each observation group were higher than those in control group,the differences were statistically significant（P〈0.05）.Conclusion：Atorvastatin obviously improves vascular endothelial function of patients with coronary slow flow.