1241例非依赖性假性血小板减少的临床分析

Clinical analysis of 1241 patients with non dependent pseudo thrombocytopenia

目的分析非依赖性假性血小板减少患者的临床疾病分布、人群分布以及季节分布的特点,并分析患者对不同抗凝剂的依赖性,以提供相应的临床解决方案。方法收取1 241例非依赖性假性血小板减少患者的标本,分别采用乙二胺四乙酸二钾（EDTA-K2）、枸橼酸钠和肝素进行抗凝,采血后立即进行相关仪器法和手工法（草酸胺）的检测。结果在1 241例患者标本中采用EDTA-K2抗凝时全部聚集,采用枸橼酸钠和肝素进行抗凝时分别有413例和91例凝聚,分别占标本总数的33.3%和7.3%;疾病中以肿瘤及放化疗患者最多,占25.7%,自身免疫性疾病、肝胆系统疾病及呼吸系统疾病分别占18.1%、14.7%和10.4%;季节中以冬季比例最高,达38.1%,夏季最低,仅占13.9%;人群中以41岁~60岁年龄组最多,达46.5%,〈10岁组最低,仅占1.3%。结论非依赖性假性血小板减少与患者的疾病类型、年龄及季节有关,更换抗凝剂可以为血小板的临床检测提供帮助。

Objective To analyze the clinical disease distribution,population distribution and seasonal distribution of non dependent pseudo thrombocytopenia patients. Meanwhile,to analyze the dependence of different anticoagulants,so as to provide the corresponding clinical solutions. Methods The samples of 1 241 cases of non dependent pseudo platelet reduce thrombocytopenia patients were anticoagulated by ethylenediamine tetraacetic acid dipotassium（ EDTA- K2）,citric acid sodium and heparin anticoagulant,respectively. Blood samples were immediately detected by related instrument method and manual method（ oxalic acid amine）. Results All 1 241 pecimens with EDTA- K2 anticoagulant gathered,413 and 91 cases gathered with sodium citrate and heparin anticoagulant,respectively,accounting for 33. 3% and 7. 3% of the total number of specimens. Among them,tumor and patients treated with radiotherapy and chemotherapy accounted for 25. 7%; autoimmune disease,hepatobiliary system diseases and respiratory system diseases accounted for 18. 1%,14. 7% and 10. 4%,respectively. Among the four seasons,winter was the highest with the proportion up to 38. 1%,while the lowest was in summer,only accounting for 13. 9%. Up to 46. 5% patients were among 41- 60 age group,while only 1. 3% were in less 10 years old. Conclusion Non dependent pseudo thrombocytopenia is correlative with clinical disease,age and seasonal distribution,and the exchange of anticoagulants can help the clinical detection of thrombocyte.