摘要
目的检测Th17细胞相关细胞因子白细胞介素-17(interleukin 17,IL-17)在慢性分泌性中耳炎(chronic otitis media with effusion,COME)患者中耳积液及外周血中表达水平,探讨COME发病中的可能作用。方法通过流式微球分析法检测30例(48耳)COME患者中耳积液、外周血浆及20例健康对照组外周血浆中IL-17的表达水平。结果 IL-17在中耳积液中含量显著高于同组患者外周血浆中含量(P<0.05),而后者高于健康对照组血浆中含量(P<0.05)。结论 IL-17作为重要的免疫介质可能与COME的慢性持续状态有关。
OBJECTIVE To study the role of interleukin 17（IL-17） in the pathogenesis of chronic otitis media with effusion（COME）.METHODS The expression of IL-17 in middle ear effusion（MEE） and blood plasma were measured in 30 patients（48 ears） by means of Cytometric Bead Array（CBA）,as well as in 20 normal volunteers.RESULTS Compared with the control group,the level of IL-17 significantly increased in the peripheral blood of COME patients（P〈0.05）.What was more,the level of IL-17 in the MEE was higher than that in peripheral blood of COME patients（P〈0.05）.CONCLUSION IL-17,as an important immunoregulatory mediator,may play an important role in chronic course of COME.
出处
《中国耳鼻咽喉头颈外科》
CSCD
2016年第5期273-274,共2页
Chinese Archives of Otolaryngology-Head and Neck Surgery
基金
国家自然科学基金资助项目(81070777)
