BPH相关LUTS与各临床影响因素关系的研究

Relationship between lower urinary tract symptoms and clinical factors in patients with benign prostatic hyperplasia

目的 研究前列腺增生症（BPH）相关下尿路症状（LUTS）与各临床影响因素的关系.方法 选择本院收治的146例BPH患者为研究对象,采用回顾性调查法分别调查本组患者的病历资料,包括年龄、病程、前列腺体积、前列腺特异抗原（PSA）、前列腺增生家族史、情绪、血清雌激素等.以患者下尿路症状严重程度为因变量,以可能导致患者下尿路症状加重的各类因素为自变量,先进行单因素分析,单因素分析后再运用Logistic回归分析工具进行多因素分析.结果 单因素分析结果显示,年龄、最大尿流量、PSA、HAMD评分及血清雌激素均是影响BPH相关LUTS严重程度的重要因素（P＜0.05）;Logistic多因素回归分析结果显示,年龄、最大尿流量、PSA及血清雌激素是影响BPH相关LUTS严重程度的独立危险因素（P＜0.05）.结论 年龄增长、最大尿流量＜5mL/s、PSA升高及血清雌激素升高均是加重前列腺增生症相关下尿路症状严重程度的重要危险因素.

Objectives To study the relationship between lower urinary tract symptoms （LUTS）and clinical factors in patients with benign prostatic hyperplasia （BPH）.Methods 146 cases of BPH patients were taken as the research object.Age,duration of disease,prostate volume,prostate specific antigen（PSA）,prostate hyperplasia,emotion,serum estrogen and so on were compared and analysed by retrospective investigation method.In patients with LUTS as the dependent variable,in order to lead to the patients with LUTS of all kinds of factors as independent variables,medical records were compared with Logistic regression anaysis after single factor analysis.Results Age,maximum urinary flow,HAMD,PSA score and serum estrogen were important factors （P 〈 0.05）.Logistic regression analysis showed that age,maximum urine flow,PSA and serum estrogen were independent risk factors （P 〈 0.05）.Conclusions Age increasing,maximum urine flow rate （〈 5mL/s）,PSA and serum estrogen level are important risk factors for the severity of LUTS associated with BPH.