期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

趋化因子受体CXCR4与肾癌转移研究进展 被引量：1

原文传递
导出
摘要 肾癌作为泌尿系统最常见的恶性肿瘤之一,发生转移后预后差,死亡率高.CXCR4被认为和肾癌转移有重要关系.CXCL12/CXCR4生物轴引导高表达CXCR4的肾癌细胞转移到靶器官.CXCR4信号通路被证实与肾癌细胞的存活、增殖、侵袭等密切相关.本文总结国内外关于CXCR4在肾癌的研究进展,尤其是CXCR4在细胞内信号通路的研究进展,系统综述CXCR4促红肾癌转移机制、临床应用情况及与肾癌预后的研究进展.
作者 王志向 王林辉
机构地区 第二军医大学附属长征医院泌尿外科
出处 《国际泌尿系统杂志》 2016年第3期443-447,共5页 International Journal of Urology and Nephrology
基金 国家自然科学基金（81272817/H1619）
关键词 肾肿瘤 肿瘤转移 受体 趋化因子
分类号 R737.11 [医药卫生—肿瘤]
  • 相关文献

参考文献36

  • 1Siegel RL, Miller KD, Jemal A. Cancer statistics[ J]. CA Cancer J Clin, 2015, 65(1) :5 -29.
  • 2Torre LA, Bray F, Siegel RL, et al. Global cancer statistics [ J ]. CA Cancer J Clin, 2015.
  • 3Muller A, Homey B, Soto H, et al. Involvement of chemokine recep- tors in breast cancer metastasis[J]. Nature, 2001,410(6824) :50 -56.
  • 4Sun CY, Zang YC, San YX, et al. Proteomic analysis of clear cell renal cell carcinoma. Identification of potential tumor markers[ J]. Saudi Med J, 2010, 31 (5) :525 - 532.
  • 5Gassenmaier M, Chen D, Buchner A, et al. CXC chemokine recep- tor 4 is essential for maintenance of renal cell carcinoma - initiating cells and predicts metastasis[ J]. Stem Cells, 2013, 31 (8) :1467 - 1476.
  • 6Kang H, Watkins G, Parr C, et al. Stromal cell derived factor - 1 : its influence on invasiveness and migration of breast cancer cells in vitro, and its association with prognosis and survival in human breast cancer[J]. Breast Cancer Res, 2005, 7(4) :R402 -410.
  • 7Wang L, Wang Z, Yang B, et al. CXCR4 nuclear localization fol- lows binding of its ligand SDF - 1 and occurs in metastatic but not primary renal cell carcinoma[ J ]. Oncol Rep, 2009, 22 (6) :1333 - 1339.
  • 8Wang L, Wang L, Yang B, et al. Strong expression of chemokine re- ceptor CXCR4 by renal ceil carcinoma ceils correlates with metas- tasis[J]. Clin Exp Metastasis, 2009, 26(8) :1049 -1054.
  • 9Chen L, Wu F, Xiao WH, et al. CXCR4 gene transfer contributes to in vivo reendothelialization capacity of endothelial progenitor cells [J]. Cardiovasc Res,2010,88(88) :462 -470.
  • 10Sun Y, Mao X, Fan C, et al. CXCL12 - CXCR4 axis promotes the natural selection of breast cancer cell metastasis [ J ]. Tumour Bi- ol, 2014,35(8) :7765 -7773.

二级参考文献29

  • 1Balkwill F. The significance of cancer cell expression of the chemokine receptor CXCR4 [J].Semin Cancer Biol, 2004,14:171- 179.
  • 2Darash Yahana M,Pikarsky E,Abramoviteh R,Zeira E,Pal B, Karplus R,et al. Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis [J].Faseb J, 2004,18 : 1240-1242.
  • 3Zeelenberg I S,Ruuls Van Stalle L,Roos E. The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases[J]. Cancer Res, 2003,63 : 3833 -3839.
  • 4Pan J,Mestas J,Burdick M D,Phillips R J. Thomas G V,Reckamp K,et al. Stromal derived factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis[J]. Moi Cancer, 2006,5:56.
  • 5Jacobson O, Weiss I D, Szajek L, Farber J M, Kiesewetter D O. 64Cu AMD3100-a novel imaging agent for targeting chemokine receptor CXCR4[J]. Bioorg Med Chem, 2009,17:1486 -1493.
  • 6Hirbe A C,Morgan E A,Weilbaecher K N. The CXCR4/SDF-1 chemokine axis: a potential therapeutic target for bone metas tases[J]? Curr Pharm Des, 2010,16 : 1284-1290.
  • 7Ding,Y,Li M,Zhang J,Li N,Xia Z, Hu Y,et al. The 73 -kDa heat shock cognate protein is a CXCR4 binding protein that regulates the receptor endocytosis and the receptor mediated ehemotaxis[J]. Mol Pharmacol, 2006,69 : 1269- 1279.
  • 8Wang L,Wang Z, Yang B, Yang Q, Sun Y. CXCR4 nuclear 1o calization follows binding of its ligand SDF-1 and occurs in metastatic but not primary renal cell carcinoma[J]. Oncol Rep, 2009,22 : 1333-1339.
  • 9Tashiro K, Tada H, Heilker R, Shirozu M, Nakano T, Honjo T. Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins[J]. Science, 1993, 261: 600- 603.
  • 10Lotan D, Sheinberg N, Kopolovic J, Dekel B. Expression of SDF-1/CXCR4 in injured human kidneys[J]. Pediatr Nephrol, 2008,23:71-77.

共引文献3

同被引文献7

引证文献1

二级引证文献2

国际泌尿系统杂志
2016年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部