神经母细胞瘤相关基因DDX1研究进展

Research Progress on the DDX1 Gene Related to Neuroblastoma

神经母细胞瘤(neuroblastoma,NB)是儿童常见恶性肿瘤之一。MYCN基因扩增与NB不良预后密切相关,但MYCN基因作为NB临床诊断重要分子标志物存在一定局限性。研究表明,与MYCN基因邻近的DEAD box 1基因(DDX1)在NB中存在与MYCN共扩增现象。DDX1蛋白是DEAD box家族中一员,目前研究显示其可能是一种依赖ATP的RNA解螺旋酶,与肿瘤发生发展关系密切,但DDX1基因对NB的作用尚不清楚,且DDX1与MYCN基因共扩增对NB患者预后影响也存在分歧。文章根据目前DDX1基因与NB研究进展,对DDX1与NB关系进行综述。

Neuroblastoma（NB） is one of the common malignant tumor of children.MYCN gene amplification is strongly correlated with poor prognosis of NB.But there are still some limitations that MYCN is regarded as an important clinical molecular markers for NB diagnosis.DEAD box 1（DDX1）,a gene nearby MYCN,has recently been reported to be preferentially amplified in NB with MYCN amplification.DDX1 protein belongs to DEAD box protein family,putative ATP-dependent RNA helicases.However,the role of amplification of DDX1 in NB is unclear,and the effect of co-amplification of DDX1 with MYCN on the prognosis of patients with NB also exists great distinctions.According to the current researches on DDX1 and NB,the relationship between DDX1 and NB was reviewed.