SNP rs10876864与汉族人白癜风临床表型相关性研究

Association Study of SNP rs10876864 and Clinical Features of Vitiligo in Chinese Han Population

目的探讨12q13.2区域单核苷酸多态(SNP)rs10876864位点与白癜风临床表型(发病年龄、家族史、临床类型、伴发疾病)的相关性。方法选取6 857例患者和12 025例正常对照的(本课题组前期白癜风GWAS数据)rs10876864位点基因分型数据,χ~2检验用于比较各组间基因型和等位基因频率的分布。结果 12q13.2区域rs10876864位点基因型分布在早发型(发病年龄≤20岁)患者与晚发型(发病年龄>20岁)患者(P_(基因型)=5.10×10^(-5)),不伴发免疫性疾病患者与伴发免疫性疾病患者(P_(基因型)=1.38×10(-3)),局限型白癜风患者、寻常型白癜风患者、泛发型白癜风患者及肢端型白癜风患者(P_(基因型)=5.00×10^(-3))之间差异均具有统计学意义。结论 12q13.2区域rs10876864位点基因型分布影响白癜风发病年龄、临床类型及伴发免疫性疾病。

Objective To investigate the associations between rs10876864 in 12q13.2 and phenotype including age at onset, familial history, clinical types, concomitant disease of vitiligo in the Chinese Han population. Meth- ods The genotyping data of rs10876864 of 6 857 vitiligo patients and 12 025 normal control selected from the early vitiligo GWAS data. x2test used for the comparison between groups of genotype and allele frequen- cy distribution. Results The frequency of genotypic distribution among SNP rs10876864 in patients with early-onset （≤20） vitiligo patients and late-onset （〉20） vitiligo patients （Psonotype =5.10 × 10-5）, gen- eralized vitiligo patients with and without immune-related diseases （ Pgono,yr＊ = 1. 38 × 10 -3 ）, clinical types of vitiligo including focal vitiligo, vulgaris vitiligo, universal vitiligo, acrofacial vitiligo （ Psnotypo = 5.00 × 10-3） all have a statistical significance. Conelusion The frequency of genotypic distribution of SNP rs10876864 have statistical significance with age at onset, familial history, clinical types, concomitant dis- ease of vitiligo in the Chinese Han population.