维持皮肤屏障研究进展--脂质的分泌及组成

Advancement in Maintaining Skin Barrier—Secretion and Composition of Lipid

皮肤屏障不仅能够阻挡外界有害物质对人体的伤害,还能防止体内营养物质和水分的流失。本文综述了与皮肤屏障相关的脂质分泌过程及其主要成分,如神经酰胺(ceramides,CERs)、游离脂肪酸(free fatty acid,FFAs),胆固醇(cholesterol,CHOL)等的含量、结构或比例的变化对皮肤屏障的影响研究进展。以期为开发针对维持和修复皮肤屏障功能的护肤产品和洗涤用品等提供理论依据。

Human skin barrier has an important role in protecting and defense, reflected in the not only be able to re- sist harmful substances into the human body, but also to prevent loss of body water and nutrients, etc. Once the skin barrier is damaged, there will be dry, scaling, wrinkles and a series of skin problems. In this pa- per,we reviewd the secretion of skin lipids and the lipid composition like eeramides, free fatty acids and cho- lesterol about the skin barrier function and structure. Hope to provide a theoretical basis for the development of maintenance and repair of the skin barrier function for skin care products.