RBM3在胃癌组织和转移淋巴结中的表达及其临床意义

目的探讨RNA结合基序蛋白3（RBM3）在胃癌组织和转移淋巴结中的表达及其临床意义。方法免疫组织化学法测定80例胃癌组织和癌旁正常组织及清扫淋巴结dgRBM3表达量并予以比较。结果RBM3在胃癌和正常胃黏膜中的阳性表达率分别为82．5％（66／80）和36.3％（29／80），两者差异有统计学意义（P〈0．01）。阳性淋巴结RBM3的表达率为78．4％（58／74），和胃癌组织的表达率差异无统计学意义（P〉0.05）。胃癌RBM3的表达与胃癌肿瘤浸润深度和肿瘤分化程度有关（P〈0．05），阳性淋巴结中RBM3的表达和原发肿瘤的分化程度有关（P〈0．05）。结论RBM3在胃癌组织和阳性淋巴结中高表达，与肿瘤细胞分化程度和（或）肿瘤浸润深度有关，可以作为胃癌恶性度和预后的判定指标。

Objective To explore the expressions of RNA-binding motif protein 3 （ RBM3 ） in gastric carcinoma and their clinical significances. Method The expression of RBM3 were detected by immunohistoehemical staining in 80 patients with gastric carcinoma. Results The positive expression rate of RBM3 in gastric carcinoma （ 82.5% ） was significantly higher than that in normal tissue （ 36.3% ） . The positive expression rate of RBM3 in metastatic lymph node （ 78.4% ） had no different with that in primary gastric carcinoma. The positive expression of RBM3 in gastric carcinoma was significantly associated with the depth of invasion and tumor differentiation, The positive expression of RBM3 in metastatic lymph node was significantly associated with tumor differentiation. Conclusion The expressions of RBM3 were higher in gastric carcinoma and metastatic lymph node than in normal tissue. They were correlated to tumor differentiation or tumor-infiltrating, the detection of RBM3 can be used as biomarkers to predict tumor malignancy and prognosis of those patients.