Klotho蛋白与慢性肾脏病关系的研究进展

Research progress of the relationship between klotho protein and chronic kidney disease

Klotho基因与衰老密切相关,具有多种生物学效应,包括调节矿物质代谢、抗凋亡、抗氧化应激和抗衰老等.该基因的缺陷导致类似人类衰老的症状,如寿命缩短、动脉粥样硬化、皮肤萎缩、高磷血症等.这些表现很多与慢性肾脏病的临床表现具有相似性.在不同病因导致的慢性肾脏病中,Klotho蛋白的转录及表达均下调,视为Klotho缺乏状态.笔者就近年来Klotho蛋白与慢性肾脏病关系的研究进展作一综述.

Klotho gene is closely related to the aging,which plays an important role in modulation of mineral metabolism,anti-apoptosis,anti-oxidation and antisenescence,etc.Klotho deficiency leads to a syndrome resembling aging,such as shortened life span,atherosclerosis,skin atrophy,hyperphosphatemia,etc.This performance is similar to that of the patients with chronic kidney disease （CKD）.The levels of klotho expression and transcription are down-regulated in CKD resulted from various causes.Thus,CKD may be viewed as a state of accelerated aging and/or an age-related disease associated with Klotho deficiency.This article reviewed the relationship between Klotho and CKD.