脑损伤后高血糖对大鼠血-脑屏障通透性的影响

Effcect of Hyperglycemia on Permeability of Blood-Bra in Barrier After Brain Injury in Rats

目的 :研究脑损伤后高血糖对大鼠血 脑屏障通透性的影响。方法 :雄性Wistar大鼠 4 0只 ,随机分为 4组 :正常对照组 (Ⅰ组 ) ,高血糖组 (Ⅱ组 ) ,脑损伤后正常血糖组 (Ⅲ组 ) ,脑损伤后高血糖组 (Ⅳ组 )。应用流体冲击装置制作大鼠脑损伤模型 ,然后分别对高血糖及正常血糖组的血 脑屏障结构的损伤的标记物伊文蓝含量进行测定。结果 :在相同脑损伤的情况下 ,高血糖组的伊文蓝含量明显高于正常血糖组 (P <0 .0 1) ;同时以上 2组的伊文蓝含量均高于正常对照组及高血糖组 (无脑损伤组 ,P <0 .0 0 1) ;而正常对照组与高血糖组的伊文蓝含量无明显差异 (P >0 .0 5 )。结论 :脑损伤后高血糖使大鼠血

﨩bjective: [WT5'BZ]Our aim was to study the relatio nship between the permeability of blood brain barrier and blood glucose after b rain injury in rats. [WT5'HZ]Methods:[WT5'BZ]Forty male rats were devided int o 4 groups :normal control group, hyperglycemia without injury, normal glucose level after injury,and hyperglycemia after injury. A fluid device was used t o make injury model. Evans blue was used as a passive permeability marker. [W T5'HZ]Results: [WT5'BZ]Permeability of blood brain barrier to Evans blue s ignificantly increased in hyperglycemic rats compared with normoglycemic and c ontrol groups. [WT5'HZ]Conclusion: [WT5'BZ]Hyperglycemia increase the permeab ility of blood brain barrier after brain injury in rats. [WT5'HZ]