黄体酮和补佳乐对稽留流产清宫术后宫腔粘连的防治作用

Preventive and therapeutic effect of progesterone and progynova for intrauterine adhesion after uterine curettage of missed abortion

目的探讨黄体酮和补佳乐对稽留流产清宫术后宫腔粘连的防治作用。方法选择2012年1月-2014年12月在诸暨市妇幼保健院被诊断为稽留流产行清宫术的患者104例作为研究对象,将其分为黄体酮联合补佳乐组(观察组)和对照组,比较两组患者的术后出血情况、术后腹痛情况、术后月经情况以及术后宫腔粘连情况。结果观察组的术后出血时间低于对照组(P<0.05),出血量少于对照组(P<0.05),轻度疼痛患者所占的比例高于对照组(P<0.05),中度和重度疼痛患者所占的比例均低于对照组(P<0.05),闭经和月经减少患者所占的比例低于对照组(P<0.05),月经正常患者所占的比例高于对照组(P<0.05),月经复潮时间低于对照组(P<0.05),术后宫腔粘连的发生率低于对照组(P<0.05)。结论黄体酮联合补佳乐治疗可以减少稽留流产行清宫术患者的术后出血量和出血时间、减少术后疼痛程度、促进术后月经恢复以及降低术后宫腔粘连的发生率。

Objective To explore the preventive and therapeutic effect of progesterone and progynova for intrauterine adhesion after uterine curettage of missed abortion. Methods A total of 104 patients who were diagnosed as missed abortion and underwent uterine curettage in the hospital from January 2012 to December 2014 were selected and divided into progesterone combined with progynova group （ observation group） and control group. Postoperative bleeding, abdominal pain, menstruation, and intrauterine adhesion in the two groups were compared. Results Postoperative bleeding time in observation group was statistically significantly shorter than that in control group （P〈0. 05 ）, the amount of bleeding in observation group was statistically significantly less than that in control group （ P〈0. 05 ）, the proportion of patients with mild pain in observation group was statistically significantly lower than that in control group （ P〈0. 05 ）, the proportions of patients with moderate and severe pain in observation group were statistically significantly lower than those in control group （P〈0. 05 ）, the proportions of patients with amenorrhea and hypomenorrhea in observation group were statistically significantly lower than those in control group （ P〈0.05 ） , the proportion of patients with eumenorrhea in observation group was statistically significantly higher than that in control group （ P〈0.05 ）, the recovery time of menstruation in observation group was statistically significantly shorter than that in control group （ P〈0. 05 ）, the incidence rate of postoperative intrauterine adhesion in observation group was statistically significantly lower than that in control group （P 〈 0. 05）. Conclusion Progesterone combined with progynova can reduce the amount of postoperative bleeding and bleeding time in patients after uterine curettage of missed abortion, reduce postoperative pain, promote postoperative recovery of menstruation, and reduce the incidence rate of postoperative intrauterine adhesion.