非小细胞肺癌与稀土元素含量的相关性研究

Relevance of non-small cell lung cancer and rare earth elements

目的大量地球物理化学、流行病学调查、营养、生化、临床研究以及动物实验的结果显示和证实稀土元素（rare earth elements，REEs）与肿瘤的发生、发展以及治疗密切相关，随着稀土的开发利用，越来越多的REEs通过不同途径进入人体，REEs对人类健康的影响及毒性作用已成为目前的研究热点。本研究探讨非小细胞肺癌（non-small cell lung cancer，NSCLC）组织中的REEs含量及分布与肿瘤大小、淋巴结转移和临床分期的相关性。方法选择符合入选条件的2013—04—01—2014—01—31赣州市肿瘤医院14例NSCLC患者，应用电感耦合等离子体串联质谱仪（inductively coupled plasma-mass spectrometry，ICp-MS／MS）测定NSCLC组织的REEs含量，并对REEs的含量及分布进行分析。结果NSCLC组织中REEs含量平均数的标准差数值最小，REEs的含量是轻稀土含量〉中稀土含量〉重稀土含量；除Y、Gd元素外，La、Ce、Pr、Nd、Sm、Eu、Dy、Ho和Er等9种REEs含量在T1～T3具有上升趋势，La、Ce、Pr、Nd、Sm、Eu、Dy和Er等REEs含量T2～T3比在T1～T2上升幅度更大，这9种REEs在T。时含量都陡然下降，且在T3时REEs含量更为分散；La、Nd、Sm、Dy、Er、Tm、Yb和Lu等REEs含量在N0～N3具有上升趋势，且在N3时REEs含量表现得更为分散；从总体分期上看，随着NSCLC分期的增加，各稀土元素的倍数差异增大，点更加分散，REEs含量在NSCLC组织中的含量也更加紊乱。La、Pr、Nd、Sm、Dy、Er和Tm等7种REEs含量随着临床分期增大而增加，与临床分期呈高度正相关。结论随着NSCLC分期的升高，REEs含量呈上升趋势，且REEs在NSCLC组织中的含量也更加紊乱，La、Pr、Nd、Sm、Dy、Er和Tm与临床分期呈高度正相关。

OBJECTIVE Many results of geophysical chemistry, epidemiology, nutrition, biochemistry, clinical studies and animal experiments have confirmed that the rare earth elements （REEs） were closely related to tumor occur- rence, development and treatment. With the development of rare earth utilization, more and more REEs enter the human body through different approaches, and the toxic effects of REEs affected on human health has become a hot topic. In this study, our aim was to detect the REEs contents and distribution characteristics of non-small cell lung cancer （NSCLC） patients and discuss the relevance with tumor size, lymph node metastasis and clinical stage. METHODS From April I, 2013 to January 31, 2014, the REEs contents were measured by inductively coupled plasma-mass spectrometry （ICP-MS / MS） in 14 cases with NSCLC in Ganzhou Cancer Hospital, and the REEs contents and distribution were analyzed. RE- SULTS The average standard deviation value of REEs in lung cancer was the minimum mostly. Light REEs content was higher than the medium REEs, and medium REEs content was higher than the heavy REEs content. In addition to the Y, Gd elements, the REEs contents of La, Ce, Pr, Nd, Sm, Eu, Dy, Ho, Er in T1 -- T3 had ascendant trends, the elements of La, Ce, Pr, Nd, Sm, Eu, Dy, Er in which T2 -- T3 were more higher than the T1 -- T2. These nine REEs concentrations in T4 were sharply decreased and the contents were more dispersed in Ta. The REEs contents of La,Nd,Sm,Dy,Er,Tm,Yb,Lu had ascendant trends in N0- N3 and the distribution characteristics were more dispersed in N3. With the increase of lung cancer staging, the multiple differences in REEs contents were increased and the distribution points were more dispersed, REEs contents in lung cancer was also more disordered. The La, Pr, Nd, Sm, Dy, Er, Tm of REEs contents increased with the clinical stage progress, and these elements were positively correlated with clinical stage. CONCLUSIONS With the staging of lung cancer increase, REEs contents have ascendant trends, and the REEs contents are more disordered. The La, Pr, Nd, Sm, Dy, Er, Tm of REEs contents is positively correlated with clinical stage.