鼠神经生长因子穴位注射治疗腰椎间盘突出症疗效观察

Therapeutic Observation of Acupoint Injection of Mouse Nerve Growth Factor for Lumbar Intervertebral Disc Herniation

目的观察注射用鼠神经生长因子穴位注射治疗腰椎间盘突出症的临床疗效。方法将120例腰椎间盘突出患者随机分为治疗组、对照1组和对照2组,每组40例。对照2组采用常规脱水治疗,治疗组在对照2组治疗基础上采用注射用鼠神经生长因子穴位注射治疗,对照1组在对照2组治疗基础上采用肌肉注射三维B注射液治疗。观察3组治疗前后腓总神经和胫后神经传导速度及VAS评分,并比较3组临床疗效。结果治疗组愈显率为97.5%,对照1组为92.5%,对照2组为85.0%,治疗组愈显率与对照1组和对照2组比较,差异均具有统计学意义(P<0.05)。3组治疗后14 d和治疗后1个月VAS评分与同组治疗前比较,差异均有统计学意义(P<0.05)。治疗组治疗后14 d和治疗后1个月VAS评分与对照1组和对照2组比较,差异均有统计学意义(P<0.05)。3组治疗后1个月胫后神经及腓总神经传导速度与同组治疗前比较,差异均有统计学意义(P<0.05)。治疗组治疗后1个月胫后神经及腓总神经传导速度与对照1组和对照2组比较,差异均有统计学意义(P<0.05)。结论注射用鼠神经生长因子穴位注射是一种治疗腰椎间盘突出症的有效方法。

Objective To observe the clinical efficacy of acupoint injection of mouse nerve growth factor in treating lumbar intervertebral disc herniation（LIDH）. Method Totally 120 LIDH patients were randomized into a treatment group, control group 1, and control group 2, 40 cases in each group. Control group 2 was intervened by dehydration therapy; the treatment group was by acupoint injection of mouse nerve growth factor in addition to the intervention given to control group 2; control group 1 was by muscular injection of Trivitamin B in addition to the intervention given to control group 2. The common peroneal nerve and posterior tibial nerve conduction velocities and Visual Analogue Scale（VAS） were observed before and after treatment, and the clinical efficacies were compared among the three groups. Result The recovery and markedly effective rate was 97.5% in the treatment group, versus 92.5% in control group 1 and 85.0% in control group 2, and the rate in the treatment group was significantly different from that in control group 1 and 2（P〈0.05）. Respectively 14 d and a month after intervention, the VAS scores were significantly different from that before treatment in the three groups（P〈0.05）. Respectively 14 d and 1 month after the intervention, the VAS score in the treatment group was significantly different from that in control group 1 and 2（P〈0.05）. The common peroneal nerve and posterior tibial nerve conduction velocities a month after the intervention were significantly different from that before the intervention in the three groups（P〈0.05）. A month after the intervention, the posterior tibial nerve and peroneal nerve conduction velocities in the treatment group were significantly different from that in control group 1 and 2（P〈0.05）. Conclusion Acupoint injection of mouse nerve growth factor is an effective way in treating LIDH.