重氮参与的过渡金属催化C—H烷基化反应研究进展

Progress in Diazo Compounds Mediated Transition-MetalCatalyzed C—H Alkylation

重氮化合物是一类环境友好、高效的反应试剂,已经被广泛应用于金属卡宾C—H插入反应.近些年,重氮化合物在一种新型的催化模式下参与到过渡金属催化的C—H活化反应中,能够实现芳烃和杂芳烃C—H键的烷基化反应.综述了各种金属催化下重氮化合物参与的C—H烷基化反应,以及相关的环化反应的最新研究进展,主要介绍各反应的特点、反应机理和合成应用,并展望它的发展前景.

Diazo compounds had been widely employed as a class of environment friendly and highly efficient coupling reagents in transition-metal-catalyzed C—H bonds insertion reactions. Recently, C—H alkylation of various arenes and heteroarenes has been achieved enormous successes using diazo compounds as the alkylation reagents under a new catalytic model. The recent progress in diazo compounds mediated transition-metal-catalyzed C—H alkylation and tandem C—H alkylation/cyclization is reviewed, including reaction mechanism and synthetic applications. Furthermore, the prospects of this reaction are also discussed.