离子液体/相转移催化剂促进的二茂铁基查尔酮的合成

Facile Synthesis of Ferrocenylchalcone Promoted by Ionic Liquid or Phase-Transfer Catalyst

乙酰基二茂铁与芳香醛在离子液体或相转移催化剂作用下进行Claisen-Schmidt缩合,高产率地合成二茂铁基查尔酮.其中,相转移催化剂能更有效地催化该反应,优化后的反应条件为:无水乙醇溶液,35℃,n(乙酰基二茂铁)∶n(芳香醛)∶n(四丁基六氟磷酸铵)∶n(NaOH)=1∶1∶2.5∶0.75.

The Claisen-Schmidt condensation of acetylferrocene with arylaldehydes in the presence of ionic liquids（ILs） or phase-transfer catalysts（PTCs） provided the corresponding ferrocenylchalcones in high yields, and PTCs can promote the condensation reaction better than those of ILs. Optimum conditions were as follows： molar ratio of acetylferrocene, arylaldehyde, n-Bu_4NPF_6 and NaOH is 1∶1∶2.5∶0.75, and the appropriate reaction temperature is 35 ℃ in anhydrous Et OH.