盐酸氨溴索不同给药方式对早产儿肺透明膜病的预防效果研究

The preventive effect of different delivery ways of ambroxol hydrochloride on hyaline membrane disease in newborns

目的:探讨盐酸氨溴索不同用药方式对早产儿肺透明膜病(HMD)的预防效果。方法:选取2012年1月至2014年12月我院收治的145例早产儿,按照给药方式不同分为4组,分别为静脉给药组、静脉雾化给药组、雾化给药组及对照组,通过监测血氧饱和度和第3天的X线胸片,比较各组HMD的发病率、胸片表现、血氧饱和度开始下降的时间及并发症的发生率。结果:静脉给药组和静脉雾化给药组HMD发病率、并发症的发生率、病情严重程度均低于对照组,血氧饱和度开始下降的时间晚于对照组,差异有统计学意义(P<0.05)。结论:盐酸氨溴索能有效预防HMD,降低HMD发病率及并发症的发生率,减轻病情严重程度,且静脉和静脉联合雾化给药效果优于单纯雾化给药。

Objective： To explore the preventive effect of ambroxol hydrochloride delivered by different ways on hyaline membrane disease in newborns. Methods： 145 premature infants admitted to our hospital were divided randomly into 4 groups： intravenous injection delivered group,intravenous injection plus atomizing inhalation delivered group,atomizing inhalation delivered group,and control group. We monitored the transcutaneous oxygen saturation and chest X-ray after three days,compared the incidence and severity of HMD,neopathy and the time transcutaneous oxygen saturation start to decrease among the 4 groups. Results： The incidence and neopathy of HMD were lower,and the onset time was longer in intravenous injection delivered group and intravenous injection plus atomizing inhalation delivered group than those in control group（ P〈0. 05）. Conclusion： Intravenous injection and intravenous injection plus atomizing inhalation of ambroxol hydrochloride can prevent the incidence of HMD,neopathy,and postpone the onset time,the effects are better than atomizing inhalation only,worthy of clinical promotion.