糖尿病视网膜病变血-视网膜屏障的损伤机制被引量：6

The mechanism of blood retinal barrier impairment in diabetic retinopathy

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摘要糖尿病严重影响了视网膜微循环，从而引起一系列组织结构的病理改变。这些改变最终可导致内皮细胞过度增生，血管通透性改变，异常的视网膜血管形成并发视力减退。本文阐述了高血糖对视网膜微血管系统的影响，从细胞功能和分子生物学的角度阐明高血糖所导致的细胞损伤效应。高血糖可通过影响细胞连接功能、诱导细胞凋亡以及改变细胞间的相互作用等方式对视网膜血管细胞造成损伤。这将为人们了解糖尿病视网膜病变发生发展中的分子及细胞缺陷提供新思路。 Diabetes mellitus seriously affects retinal microcirculation, which causes a series of pathological changes of tissue structure. These changes may eventually lead to abnormal proliferation of endothelial cells, the changes of vascular permeability and abnormal formation of retinal blood vessels, which cause the loss of vision. This review describes the effects of high blood glucose on retinal microvascular system, and the damage effect caused by high blood glucose from the perspectives of cell function and molecular biology. High blood glucose can impair retinal vascular cells by affecting cell junctions, inducing apoptosis, changing the interactions between cells and so on. This study will provide a new insight into understanding the molecular and cellular defects in the development of diabetic retinopathy.

作者丁舟王杨宁致张喆蒋沁

机构地区南京医科大学附属眼科医院

出处《国际眼科纵览》 2016年第2期98-103,共6页 International Review of Ophthalmology

关键词糖尿病视网膜病变血-视网膜屏障血管细胞 diabetic retinopathy blood-retinal bala＇ier vascular cells

分类号 R587.2 [医药卫生—内分泌]

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