补体因子H基因在湿性年龄相关性黄斑变性治疗中的作用

The effect of complement factor H gene on treatment of wet age-related macular degeneration

年龄相关性黄斑变性（age—related macular degeneration，AMD）是一种与年龄、环境、基因相关的多因素退行性眼底病。补体因子H（complement factor H，CFH）是补体系统中重要的免疫抑制因子，其基因突变可导致CFH的免疫抑制作用减弱，在AMD发病中起一定的作用。CFH不仅与AMD易感性有关，而且在一定程度上影响湿性AMD抗血管内皮生长因子（vascular endothelial growth factor，VEGF）治疗后的视力提升。本文就CFH基因在湿性AMD发病机制中的作用及其对抗VEGF治疗效果的影响进行综述，为临床指导湿性AMD治疗预测AMD疗效提供新的思路。

Age-related macular degeneration（AMD） is a muhifactorial disease that results from the combined contribution of age, environment and genetic predisposition. Complement factor H （CFH） is an important inhibitor in complement system. The variant in CFH can decrease the inhibiting effect in complement pathway, which may play an important role in AMD pathogenesis. Research indicates that SNPs （single nucleotide polymorphisms） in CFH not only have strong associations with AMD susceptibility but also affect the visual acuity improvement in anti-VEGF（vascular endothelia growth factor） therapy. This article focus on the association between CFH and the pathogenesis or treatment response of anti-VEGF therapy in wet AMD and ponit out a new way to predict response to anti-VEGF treatment of wet AMD in clinical setting.