Wilms瘤基因1表达与急性髓系白血病长期预后关系的Meta分析

A Meta analysis of predictive value of Wilms tumor gene 1 level on long-term outcome of acute myeloid leukemia

目的探讨Wilms瘤基因1（WT1）基因表达水平与急性髓系白血病（AML）长期预后的关系。方法计算机检索PubMed、Science Direct、EBSCO、Web of Science、CNKI、VIP和万方数据库，收集符合纳入标准的研究，检索时限均为从建库至2015年3月，由两位研究者根据纳入与排除标准独立筛选文献、提取资料并评价质量后，采用RevMan5．2软件进行Meta分析。结果共纳入11个研究，合计1497例患者。Meta分析结果显示：wn基因高表达是AML患者总生存率（OS）及无病生存率（DFS）的不利因素[HR=1．34，95％C／1．14～1．58，P〈0．01；HR=1．35，95％C／1．11～1．64，P=0．003]；对于正常核型的AML患者，wT1基因高表达仍是OS的不利因素[HR=1．41，95％C／1．01～1．99，P=0．05]。结论WT1基因表达水平是预测AML长期预后的有效指标。

Objective To explore the predictive value of Wilms tumor gene 1 （WT1） level on long-term outcome of acute myeloid leukemia（AML）. Methods The study in accordance with the inclusion criteria were collected by computer retrieving PubMed, ScienceDirect, EBSCO, Web of Science, CNKI, VIP and Wan Fang database. The retrieval time was from inception to March 2015, the two researchers according to the inclusion and exclusion independently selected studies and extracted the data and assessed the quality, then Revman 5.2 was used for Meta analysis. Results There were 11 relevant published articles were included with 1497 case patients. Meta analysis showed that High expression of WT1 gene was a negative factor for overall survival rate （OS） and disease free survival （ DFS ） in patients with AML （ HR = 1.34,95% CI 1.14-1.58, P 〈 0. 01 ; HR = 1.35,95%CI 1.11-1.64 ,P= 0. 003 ）. For cytogenetically normal AML patients, the high expression of WT1 gene was still the unfavorable factor of OS（HR= 1.41,95%CI 1.01-1.99,P=0.05） .Conclusion WT1 expression level could be an useful prognosis lone-term outcome marker for AML patients.