摘要
造血干细胞（HSC）是一种多能干细胞，是各种血液细胞与免疫细胞的起始细胞。HSC移植（HSCT）是指去除异常的骨髓造血细胞，然后植入健康的HSC，使之重建造血与免疫系统，这是一种可以治愈血液系统恶性肿瘤以及治疗遗传与代谢性疾病、免疫系统疾病和实体瘤的有效方法，目前已经广泛应用于血液系统恶性肿瘤的治疗中，如淋巴瘤、白血病等。有报道显示，白血病合并银屑病患者，在应用HSCT治疗白血病时，不仅治愈了白血病，同时也缓解甚至治愈了银屑病。现就银屑病的免疫发病机制、HSCT在自身免疫性疾病中的应用、银屑病合并白血病的可能机制、HSCT在治疗白血病合并银屑病中的应用现状等方面进行综述。
Objective Hemapoietic stem cell （HSC） is a kind of pluripotent cell which can differentiate into different kinds of cells, including blood cells and immune ceils. Hemapoietic stem cell transplantation（HSCT） is to destory abnormal bone marrow hematopoietic cells,and imbed healthy stem cells to reconstruct hematopoiesis and immune system, and it is an effective therapy for the treatment of hematopoietic malignances, genetic and metabolic disease, autoimmune disease and solid tumor. At present, it has been widely used to treat the patients with hematologial malignant tumors, such as lymphoma and leukemia. Clinical investigation showed that patients with leukemia and psoriasis after HSCT, both leukemia and psoriasis were cured. In this review, the immunopathogenesis of psoriasis, the possible mechanism of psoriasis associated with leukemia, the immunopathogenesis of HSCT and the theory basis of treating psoriasis and the application of HSCT in the treatment of psoriasis with leukemia were comprehensively discussed.
出处
《中国综合临床》
2016年第5期475-478,共4页
Clinical Medicine of China
基金
国家自然科学基金资助项目（81170489）
江苏省自然科学基金（BK20141254）
关键词
造血干细胞移植
银屑病
免疫机制
Hemapoietic stem cell transplantation
Psoriasis
immunopathogenesis
