FAM20C在骨和牙发育矿化中的作用

Function of FAM20C in osteogenesis and odontogenesis

Family with sequence similarity 20, member C （FAM20C） 又称牙本质基质蛋白4（DMP4），是一种分泌性钙结合激酶，在矿化组织中高表达，可使生物矿化相关的分泌性钙结合磷酸蛋白（scPPs）家族磷酸化，调控磷酸钙沉积，形成并影响羟基磷灰石晶体的生长和排列。FAM20C突变可致Raine综合征（又称硬化性骨发育不良），导致骨、牙发育缺陷，低磷酸血症等，新生儿致死率高。近年来研究表明，FAM20C可促进成骨细胞、成釉细胞及成牙本质细胞分化，负性调控成纤维细胞生长因子23（FGF23）影响血磷稳态，在骨和牙齿发育矿化中发挥重要作用。就FAM20C在骨和牙发育矿化中的研究现状作一综述。

Family with sequence similarity 20, member C （FAM20C）, also known as dentin matrix protein 4 （DMP4）, is a calcium-binding kinase for secreted phosphoproteins, and is highly expressed in mineralized tissues, which phosphorylates secretory calcium-binding phosphoproteins （SCPPs）, thus modulating hiomineralization. Muta- tions in FAM20C may cause the Raine syndrome, an autosomal recessive disorder characterized by generalized osteosclerosis with teeth defects, bone defects, hypophosphatemia and neonatal lethality. FAM20C plays an important role in the osteogenesis and odontogenesis through regulating the differentiation of osteoblast, ameloblast and odonto- blast, as well as suppressing the production of phosphate-regulating hormone fibroblast growth factor 23 （FGF23）. The research progress on the function of FAM20C in osteozenesis and odontogenesis is reviewed.