基于中药药性的中药提取物组合相关有效专利中菊科中药的模糊聚类分析

Fuzzy Cluster Analysis of Compositae Involved in Effective Patent of TCM Extract Combination on Drug Properties

目的:对中药提取物组合的有效专利中涉及到的菊科药用植物进行药性分类。方法:利用计算机分析软件,以性、味、归经为指标参数,对2015年1月1日以前获准且至2015年5月30日仍维持有效的中药提取物组合的相关有效专利文献中涉及最广的菊科药用植物进行模糊聚类分析。结果与结论:共涉及27种菊科中药,多具有保肝功效。将其聚为5类时,第1类包括菊花等10种中药,大多性寒、味苦、归肝经与肺经,均含有黄酮类化合物;第2类包括鼠曲草等3种中药,主要药用成分均为黄酮类化合物;第3类包括苍术等5种中药,均具有保肝作用,且均含有挥发油类成分;第4类包括款冬花等4种中药,均具有抗炎和抗肿瘤作用;第5类包括灯盏细辛等5种中药,均含有治疗心脑血管疾病的有效成分。所分各类中药不仅在性、味、归经上具有相似之处,且在有效成分及功效上也相似。相关科研人员可通过参考同一类中药中已知中药的相关信息对其中信息未知的中药药理作用等进行深入研究,可节约研究时间、扩充药用资源。

OBJECTIVE：To classify the drug properties of Compositae involved in effective patent of TCM extract combination.METHODS：Property,flavor and the meridian tropism of TCM were used as the parameters;by computer analysis software,fuzzy cluster analysis was conducted from Compositae mostly involved in effective patent of TCM extract combination which approved before Jan.1st in 2015 and kept till May 30 th in 2015.RESULTS CONCLUSIONS：27 ingredients of Compositae were involved with the functions as protecting liver almost.They were classified into 5 categories.The first category included 10 ingredients as Dendranthema morifolium which were cold,bitter to taste,and in the liver and lung meridian,and all of them contained flavonoids compounds;the second category included 3 ingredients as Gnaphalium affine of which flavonoids compounds were main medicinal components;the third category included 5 ingredients as Atractylodes lancea which could protect liver and contained volatile oil;the forth category included 4 ingredients as Tussilago farfara which showed anti-inflammatory and anti-tumor effect;the fifth category included 5 ingredients as Erigeron breviscapus which contained ingredients for cardiovascular disease.Those categories were similar not only in property,flavor and the meridian tropism,but also in active ingredients and effects.The researchers should further research TCM of which pharmacologic action are not well understood,by means of make reference to known TCM in the same category,and make preparation to save time and enlarge medicinal resource.