唐山地区2012~2014年孕早期亚临床甲状腺功能减退的调查分析

A Survey and Analysis in Pregnant Women with Subclinical Hypothyroidism in Tangshan Area from 2012 to 2014

目的了解唐山地区2012~2014年孕早期亚临床甲减（SCH）发病情况,以减低SCH对孕妇及胎儿造成的不良后果。方法对首次产检的孕妇建卡并进行游离甲状腺素（FT4）、促甲状腺激素（TSH）、甲状腺过氧化物酶抗体（TPO-Ab）、甲状腺球蛋白抗体（Tg-Ab）的检测,选取TSH〉2.5 m IU/L,FT4浓度正常的孕妇,设计专用表格,记录孕妇的体能检查指征及相关病史。结果孕妇的SCH发病率逐年升高,年龄〉30岁孕妇的SCH发病率较高,SCH孕妇复发性流产的发病风险较对照组升高,SCH孕妇的甲状腺自身抗体阳性比例较高。结论唐山地区的孕妇孕早期SCH的发病率逐年上升,且有较高的复发流产比率,应该加大对于亚甲减的早期检测、干预,降低对孕妇及胎儿造成不良后果。

Objective To study the prevalence of pregnant women with subclinical hypothyroidism（SCH） in Tangshan area in order to reduce the adverse consequences of pregnant women and fetus.Methods TSH,FT4,TPO-Ab and Tg-Ab were tested to establish medical records for the pregnant women.TSH〉2.5m IU / L and normal FT4 as the normal pregnancy.Results The prevalence of SCH in pregnant women increased over the years.The pregnant women over 30 years of age had higher prevalence.The risk of recurrent miscarriage of pregnant women with SCH was higher than that of normal group.The pregnant women with positive thyroid autoantibody had higher risk of SCH.Conclusion The prevalence of SCH in pregnant women was increasing,and recurrent miscarriage had a higher proportion.Early detection and intervention for SCH could reduce the adverse consequences of the pregnant women and fetus.