氮杂环酰胺化合物合成研究

Synthesis of Nitrogen Heterocycle-Containing Amide Derivatives

对氮杂环酰胺化合物的合成方法进行了研究：在四氢呋喃溶剂中,在催化剂4-二甲氨基吡啶存在下,以苯并噻唑胺、噻二唑胺等杂环胺和4-取代苯甲酰氯为原料,经酰胺化反应,合成了12个氮杂环酰胺化合物。产率高达83.1%~96.3%。该法原料易得、操作简单、条件温和、收率高、底物适用范围广。

A study for synthesis of nitrogen neterocycle-containing amide derivatives was provided.In this method,benzothiazolamine or thiadiazole amine reacted with benzoyl chloride in 1：1.2 molar ratio in THF with DMAP as the catalyst to form twelve amide derivatives with 83.1%~96.3% yields.The method was of readily available raw materials,simple operation,mild conditions,high yield,apply a wide range of substrates.