摘要
目的探讨以血小板减少为主要临床表现的HIV/AIDS患者临床特征、随访情况、治疗转归。方法 25例HIV/AIDS患者使用高效抗逆转录病毒治疗(替诺福韦+拉米夫定+依非韦伦),动态观察患者血小板计数、CD4+T淋巴细胞计数和HIV-RNA载量变化情况,观察基线血小板计数与治疗后CD4+T细胞计数的关系。结果 25例患者治疗1个月和6个月后,血小板计数由(22.77±13.38)×109/L上升至(63.62±16.51)×109/L和(118.69±.38.91)×109/L;CD4+T淋巴细胞计数由(152.85±93.35)个/μL上升至(206.85±102.50)个/μL和(340.00±156.84)个/μL;25例患者治疗前血浆HIV-RNA载量为2053615.32±6032243.65copies/m L,其中有18例(72%)患者在治疗6个月后病毒载量均<500.00 copies/m L;治疗前血小板≥60×109/L组的患者于治疗后CD4+T细胞计数上升至(427.16±122.56)个/μL,血小板<60×109/L组的患者于治疗后CD4+T细胞计数上升为(226.77±102.43)个/μL。患者临床症状均有明显改善;无严重机会性感染和艾滋病相关死亡事件出现。结论高效抗逆转录病毒治疗,可提升患者血小板水平,提高CD4+T淋巴细胞计数,降低HIV-RNA载量,改善患者预后和生存质量。
Objective To investigate the clinical features, follow-up and overcome of HIV/AIDS patients with prominent thrombocytopenia. Methods Twenty-five HIV/AIDS patients were treated with highly active anti-retroviral therapy. The change of the platelet counts, the CD4＋T lymphocyte counts and HIV RNA loads were tested in the course of treatment. Results After highly active anti-retroviral therapy, follow-up first month to sixth month, platelet counts from（22.77±13.38）×109/L to（63.62±16.521）×109/L and（118.69±38.91）×109/L; CD4 counts from（152. 85±93.35）cells/μL to（206.85±102.50）cells/μL and（340.00±156.84）cells/μL; the HIV RNA loads of 25 cases in prior treatment were 2053615.32±6032243.65copie/m L, after treatment of 6months, the eighteen patients had not be detected in the blood（500.00copie/m L）. After the therapy, the CD4,which belongs to the group of platelet ≧60×109/L,counts to（427.16±122.56）cells/μL. While the CD4,belonging to the group of platelet 60×109/L,counts to（226.77±102.43）cells/μL. They were significantly improved,and no opportunistic infection and HIV-related deaths occurred. Conclusion With improving the level of patients＇ platelet counts and increasing the counts of CD4＋T lymphocyte,while decreasing the loads of HIVRNA, highly active anti-retroviral therapy can effectively improve AIDS patients＇ prognosis and outcome.
出处
《泰州职业技术学院学报》
2016年第2期65-68,共4页
Journal of Taizhou Polytechnic College
