NEK2基因在口腔鳞状细胞癌中的表达及意义

The expression and significance of NEK2 mRNA in oral squamous cell carcinoma

利用Real-Time PCR检测细胞周期相关蛋白激酶2(NEK2)mRNA在20例口腔正常黏膜组织及42例口腔鳞状细胞癌(OSCC)组织中的表达。结果显示,NEK2 mRNA在OSCC中高表达(P<0.050),不同分化程度(P<0.05)、不同临床分期组间差异具有统计学意义(P<0.05)。有无淋巴结转移(P>0.05)、不同年龄、不同性别组间差异无统计学意义(P>0.05)。NEK2基因表达增高可能参与OSCC的形成。

42 cases of OSCC and 20 of healthy tissues were studied to detect the expression of NIMA-related Kinase 2（ NEK2） mRNA by Real-time PCR. Over expression of NEK2 mRNA was observed in OSCC（ z =- 6. 328,P〈0. 05）,the expression was correlated with the differentiation（ z =- 5. 012,P〈0. 05） and clinical stage（ z =- 4. 950,P〈0. 05） of the lesion,but not with the lymph node metastasis（ z=- 0. 051,P〈0. 05）,age（ z =- 0. 365,P〉0. 05） and gender（ z =- 3. 450,P〉0. 05）. NEK2 gene may be involved in the development of OSCC.