期刊文献+

原发性开角型青光眼易感基因的研究进展

原文传递
导出
摘要 在青光眼中,所占比例为50%的原发性开角型青光眼(POAG)在致盲性疾病中位居第二位,具有遗传性、渐进性和不可逆性的特点。POAG具有渐进性视盘的凹陷性萎缩和视野的特征性缺损的特点。最近研究发现,POAG除与高血压、糖尿病、遗传史、吸烟等危险因素有关外,还与遗传及基因变异有着非常紧密的联系。
作者 陈鹏 辛向阳
出处 《中国冶金工业医学杂志》 2016年第3期272-273,共2页 Chinese Medical Journal of Metallurgical industry
  • 相关文献

参考文献13

  • 1陈建华,徐亮,李杨,董冰.原发性开角型青光眼MYOC—TIGR基因突变研究[J].中华眼科杂志,2011,47(2):122-128. 被引量:6
  • 2Hewitt AW, Dimasi DP, Mackey DA, et al. A Glaucoma Case- control study of the WDR36 Gene D658G sequence variant [J]. Am J Ophthalmol,2006,142(2) :324-325.
  • 3Hauser MA, Allingham RR, Linkroum K, et al. Distribution of WDR36 DNA sequence Variants in patients with primary open angle glaucoma[J]. Invest Ophthalmol Vis Sei, 2006, 47 ( 6 ) : 2542-2546.
  • 4Hewitt AW,Bennett SL,Richards JE,et al. Myoeilin Gly252Arg mutation and glaucoma of intermediate severity in Caucasian individuals[J]. Arch Ophthalmnl, 2007,125 ( 1 ) : 98-104.
  • 5Pasutto F, Mardin CF, Miehels-Rautenstrauss K, et al. Profiling of WDR36 missense variants in German patients with glaucoma [J]. Invest Ophthalmol Vis Sci, 2008,49 (1) : 270-274.
  • 6Weisschuh N, Wolf C, Wissinger B, et al. Variations in the WDR36 gene in German patients with normal tension glaucoma [J]. Mol Vis,2007,13:724-729.
  • 7Wang L, Zhuo Y, Liu B, et al. Pro 370 Leu mutant myoeilin disturbs the endoplasm reticulum stress response and mitoehondrial membrane potential in human trabecular meshwork cells[J]. Mol Vis, 2007,13 : 618-625.
  • 8Stamer WD, Perkumas KM, Hoffman EA, et al. Coiled-coil targeting of myocilin to intracellular membranes[J]. Exp Eye Res,2006,83(6) : 1386-1395.
  • 9Thorleifsson G,Walters GB, Hewitt AW,et al. Common variants near CAV1 and CAV2 are associated with primary open angle glaucoma[J]. Nat Genet,2010,42(10) :906-909.
  • 10Tamm ER. The trabecular meshwork outflow pathways: structural and functional aspects[J]. Exp Eye Res,2009,88(4): 648-655.

二级参考文献2

共引文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部