肠易激综合征患者肠道菌群分析及应用益生菌疗效观察

Therapeutic efficacy of probiotics and analysis of intestinal flora in patients with irritable bowel syndrome

目的:对益生菌治疗肠易激综合征(IBS)的疗效进行了解,并了解治疗前后患者肠道菌群变化情况。方法:选择IBS患者40例作为观察组及性别、年龄相符合的健康人为对照组40例,借助细菌培养法做肠道5种常见菌群的定量检测,IBS患者予以益生菌治疗,对比治疗前后患者粪便中常见菌群数量的变化,并评价其疗效。结果:相较于对照组,IBS患者粪便中肠杆菌显著增加(P<0.05),双歧杆菌与乳杆菌数量少于正常人(P<0.05);治疗后粪便中双歧杆菌及乳酸杆菌含量较治疗前有极大提高(P<0.05);使用益生菌治疗后,患者治疗总有效率为62.5%。结论:IBS患者伴有肠道菌群异常,肠道定植抗力不强,通过益生菌制剂治疗可增加IBS患者肠道有益菌数量,改善其肠道症状。

Objective To study the therapeutic efficacy and intestinal flora in patients with irritable bowel syndrome（IBS） before and after treatment with probiotics. Methods 40 patients with IBS, compared with age/gender matched control subjects（40）.IBS patients were given bifid triple viable capsule treatment. Score of patients clinical symptoms was evaluated by a questionnaire. On the same time,five kinds ofcommon intestinal bacteria was analyzed by using the method of bacterial culture. Results Compared with the control group, the level of enteric bacilli was significantly higher（P 0.05）,the level of bifidobacterium and cillobacterium were significantly lower（P 0.05）;bifidobacteria and lactobacilli were higher than before treanment（P 0.05）.After taking bifid, IBS patients the effective rate was 62.5 %. Conclusion Most IBS patients have dysbacteria, probiotics can relive the symptoms of some patients with IBS by increasing the number of probiotics.